About the Conference
DEADLINE FOR THE SUBMISSION OF ABSTRACTS HAS BEEN EXTENED UNTIL 12 September 2011
Two major protein degradation pathways exist in eukaryotic cells: autophagy and the ubiquitin proteasome system (UPS). Whereas the UPS is responsible for the rapid degradation of proteins when fast adaptation is needed, autophagy is mainly involved in the degradation of long-lived proteins and entire organelles. Autophagy plays an important role during development, tumor suppression, immunity, tissue homeostasis and is required for the adaptation to environmental stresses such as starvation.
In recent years, rapid progress has been made in understanding the molecular mechanisms of autophagy and its contribution to organelle turnover, cell death regulation, prevention of ageing and neurodegenerative disorders. Interestingly, growing body of evidence suggests an interplay between autophagy and the UPS. In particular, ubiquitin may not only target proteins for proteasomal degradation, but may also serve as a recognition signal to specifically eliminate organelles and invading pathogens by autophagy.
The aim of this international conference series is to bring together scientists working on autophagy and ubiquitin-dependent mechanisms. The second meeting of this series will be devoted mainly to mechanism and regulation of autophagy with a particular focus on ubiquitin mediated selective autophagy, different aspects of autophagosomes biogenesis, and the relationship between autophagy and apoptosis. We will also cover different physiological and pathological aspects of this process with a special emphasis on cell death, immunology, neurodegeneration and cancer.
- Mechanism of autophagy
- Ubiquitin and autophagy
- Regulation of autophagy
- Autophagosome origin and biogenesis
- Selective autophagy
- Autophagy and cell death
- Role of autophagy in physiological conditions
- Autophagy and different pathologies
We look forward to welcoming you to Ma'ale Hachamisha!
|38th Conference of the Aharon