Conference Series

European Molecular Biology Organization

 

Autophagy in health and disease

30 October - 4 November, 2011 | Ma'ale Hachamisha | Israel

Programme

 

Programme can be downloaded here

 

SUNDAY, 30 OCTOBER 2011
 
Opening Session
18:00 – 20:00 (Shaked Hall)
  18:00 Welcome
  18:10 Keynote address
THE CASPASE FAMILY AND THE DEATH-FOLD: AN EVOLUTIONARY CONSERVED ASSOCIATION ON GUARD AGAINST INTRACELLULAR AND EXTERNAL DANGERS
David Wallach, Weizmann Institute of Science, Rehovot, Israel
  18:45 Discussion
  18:55 Keynote address
EPITHELIAL CELL PLASTICITY, CANCER STEM CELLS AND AUTOPHAGY
Patrice Codogno, INSERM U984, France
  19:30 Discussion
  19:45 Dinner
     
MONDAY, 31 OCTOBER 2011
 
Session 1 - Autophagosomes Biogenesis
Chair: David Rubinsztein, UK
08:30 – 10:20 (Shaked Hall)
  08:30 MOLECULAR DYNAMICS OF Atg PROTEINS DURING AUTOPHAGOSOME FORMATION IN YEAST
Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
  09:05 THE MECHANISM OF PHAGOPHORE EXPANSION
Daniel Klionsky, University of Michigan, USA
  09:40 MAMMALIAN ATG8s MEDIATE MEMBRANE FUSION
Tomer Shpilka, Weizmann Institute of Science, Rehovot, Israel
  10:00 GAPs IN AUTOPHAGY: MULTIPLE Rab GAPs ARE IMPLICATED IN THE AUTOPHAGY PATHWAY BY DIRECT BINDING TO HUMAN ATG8 MODIFIERS
Christian Behrends, Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt, Germany
  10:20 Coffee
     
 
Session 1 - Autophagosomes Biogenesis (cont.)
10:40 – 12:15 (Shaked Hall)
  10:40 REGULATION OF AUTOPHAGOSOME COMPLETION
Fulvio Reggiori, University Medical Centre Utrecht, The Netherlands
  11:15 betaA3/A1-CRYSTALLIN AS A NOVEL LYSOSOMAL COMPONENT REQUIRED BY THE RETINAL PIGMENTED EPITHELIAL (RPE) CELLS FOR AUTOPHAGY AND PHAGOCYTOSIS
Debasish Sinha, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, USA
  11:35 PROTECTIVE ROLE OF AUTOPHAGY IN LIPID DYSFUNCTION CAUSED BY HEPATITIS C VIRUS
Tiziana Vescovo, National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, Rome, Italy,
  11:55 A PHYSIOLOGICAL SYSTEM FOR SELECTIVE MITOCHONDRIAL DESTRUCTION IN DROSOPHILA
Eli Arama, Weizmann Institute of Science, Rehovot, Israel
  12:15 Lunch plus free time
   
 
Session 2 - Autophagosomes Biogenesis (cont.)
Chair: Daniel Klionsky, USA
15:00 – 16:30 (Shaked Hall)
  15:00 REGULATION OF EARLY EVENTS IN AUTOPHAGOSOME BIOGENESIS
David Rubinsztein, Cambridge University, UK
  15:35 BIOCHEMICAL AND MORPHOLOGICAL UNDERSTANDING OF MAMMALIAN Atg9
Sharon A. Tooze, London Research Institute, Cancer Research UK, UK
  16:10

STUDYING AUTOPHAGY THROUGH THE ROLE OF ULK1/2 AND MATG9, TWO ESSENTIAL AUTOPHAGY PROTEINS
Eyal Kalie, Cancer Research UK, London, UK

  16:30 Coffee
     
 
Session 2 - Autophagosomes Biogenesis (cont.)
17:00 – 18:30 (Shaked Hall)
  17:00 MAMMALIAN Atg PROTEINS IN AUTOPHAGOSOME FORMATION
Noboru Mizushima, Tokyo Medical and Dental University, Japan
  17:35 INSIGHTS INTO MEMBRANE DYNAMICS IN AUTOPHAGY
Tamotsu Yoshimori, Osaka University, Japan
  18:10

ROLE OF AUTOPHAGY AND GLUTAMATE DEHYDROGENASE IN THE CELLULAR METABOLISM OF TSC AND LAM
Andrey Parkhitko, Brigham and Women’s Hospital and Harvard Medical School, Boston MA, USA

  19:00 Dinner
  20:00 Poster Session
     
TUESDAY, 1 NOVEMBER 2011
 
Session 3 - Regulation of Autophagy
Chair: Beth Levine, USA
08:30 – 12:55 (Shaked Hall)
  08:30 KINASE NETWORKS REGULATING AUTOPHAGY IN DROSOPHILA
Thomas Neufeld, University of Minnesota, USA
  09:05 THE DISCOVERY OF MOLECULAR PATHWAYS CONTROLLING THE AUTOPHAGIC FLUX
Adi Kimchi, Weizmann Institute of Science, Rehovot, Israel
  09:40 TNF-RESISTANT BREAST CANCER CELLS ACTIVATE HYPOXIA-LIKE CELLULAR RESPONSES LEADING TO THE AUTOPHAGY ACTIVATION. INVOLVEMENT OF SPHINGOSINE KINASE-1/SPHINGOSINE-1-PHOSPHATE PATHWAY
Joanna Baginska, Public Research Center for Health (CRP-Santé), Luxembourg City, Luxembourg
  10:00 SCREENING FOR PHOSPHOINOSITIDE EFFECTORS OF AUTOPHAGY
Anne Simonsen, University of Oslo, Norway
  10:35 Coffee
  11:05 FUNCTION AND REGULATION OF Atg1 KINASE IN AUTOPHAGY
Claudine Kraft, Max F. Perutz Laboratories, University of Vienna, Austria
  11:40 EXPRESSION  OF THE AUTOPHAGY GENE ALFY IS INHIBITED IN ACUTE MYLEOID LEUKEMIA AND ITS KNOCK-DOWN  ATENUATES GRANULOCYTE DIFFERENTIATION
Anna M. Schläfli, Department of Clinical Research, University of Bern, Switzerland
  12:00 DANCE WITH THE YEAST---ATGs and EPGs
Hong Zhang, National Institute of Biological Sciences, China
  12:35 AUTOPHAGY IS REQUIRED FOR THE DIFFERENTIATION OF NEURAL STEM/PROGENITOR CELLS INTO NEURONS
Patricia Boya, CSIC, Madrid, Spain and University of Rome "Tor Vergata", Rome, Italy
  12:55 Lunch plus free time
   
 
Session 4 - Autophagy and Disease
Chair: Noboru Mizushima, Japan
15:00 – 19:10
  15:00 AUTOPHAGY - AN EVOLVING IMMUNOLOGICAL PARADIGM
Vojo Deretic, University of New Mexico, USA
  15:35 ROLE OF AUTOPHAGY AND AUTOPHAGY PROTEINS IN IMMUNITY AND INFLAMMATORY DISEASES
Herbert W. Virgin IV, Washington University School of Medicine, USA
  16:10 PHOSPHORYLATION OF OPTINEURIN PROMOTES SALMONELLA AUTOPHAGY
Ivan Dikic, Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt, Germany
  16:30 Coffee
  17:00 GENETIC ROUTES TO AUTOPHAGY FAILURE IN ALZHEIMER'S DISEASE
Ralph A. Nixon, New York University Langone Medical Center; Nathan Kline Institute, USA
  17:35 REGULATED LC3 CONVERSION IN AUTOPHAGY BY RNF5
Ze'ev Ronai, Sanford-Burnham Medical Research Institute, USA
  18:10 Regulation of Autophagy in C. elegans by RNF-5, an E3 Ubiquitin Ligase
Sharon Sheffy Levin, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  18:30 THE POSSIBLE ROLE OF CYCLOPHILINS AS LINKERS OF AGING AND PROTEIN MISFOLDING TOXICITY
Tziona Ben-Gedalya, Institute for Medical Research Israel-Canada (IMRIC), Hebrew University School of Medicine, Jerusalem, Israel
  18:50 JUN PROTEINS ARE STARVATION-CONTROLLED REGULATORS OF AUTOPHAGY
Eitan Shaulian, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
  19:00 Dinner
  20:00 Poster Session 
     
WEDNESDAY, 2 NOVEMBER 2011
 
Session 5 - Autophagy, Cell Proliferation and Cell Death
Chair: Ivan Dikic, Germany
08:30 – 10:40 (Shaked Hall)
  08:30 Ambra1 IS A RELAY MOLECULE IN THE CELL RESPONSE TO AUTOPHAGY INDUCTION
Francesco Cecconi, University of Rome "Tor Vergata", Italy
  09:05 AUTOPHAGY: A STRESS-ADAPTIVE MECHANISM FOR A LONG LIFE WITHOUT CANCER
Guido Kroemer, Institut Gustave Roussy, France
  09:40 AMBRA1 REGULATES THE LATE STAGES OF AUTOPHAGY BY MODULATING THE ACTIVITY OF THE LYSOSOMAL PROTEIN SPINSTER-1
Gian Maria Fimia, National Institute for Infectious Diseases IRCCS
‘L. Spallanzani’, Rome, Italy
  10:00 ATG16L1 DEFICIENCY CONFERS PROTECTION FROM PERSISTENT UROPATHOGENIC ESCHERICHIA COLI INFECTION IN VIVO
Indira Mysorekar, Washington University School of Medicine, St. Louis,
MO, USA
  10:20 EFFECTS OF DYNACTIN WITH A PATHOGENIC MUTATION FOR PERRY SYNDROME ON AUTOPHAGY
Kei-Ichi Ishikawa, Juntendo University School of Medicine, Tokyo, Japan
  11:00 Coffee
  Afternoon Jerusalem Tour and dinner
     
THURSDAY, 3 NOVEMBER 2011
 
Session 6 - Selective Autophagy
Chair: Adi Kimchi, Israel
08:30 – 12:55
  08:30 FUNCTIONAL CHARACTERIZATION OF Atg8-TARGETS IN AUTOPHAGY
Matthias Peter, Swiss Federal Institute of Technology, Switzerland
  09:05 A PLANT-SPECIFIC Atg8-INTERACTING PROTEIN DEFINES A NOVEL STARVATION-INDUCED BODY DISTINCT FROM AUTOPHAGOSOMES
Gad Galili, Weizmann Institute of Science, Israel
  09:40 THE AUTOPHAGY PROTEIN ATG12 ASSOCIATES WITH ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS TO PROMOTE MITOCHONDRIAL APOPTOSIS
Assaf D. Rubinstein, Weizmann Institute of Science, Rehovot, Israel
  10:00 CHAPERONE-MEDIATED AUTOPHAGY IN THE REGULATION OF THE CELLULAR ENERGETIC BALANCE
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
  10:35 Coffee
  11:05 ROLES OF LIR MOTIF-MEDIATED INTERACTIONS IN AUTOPHAGY AND EVOLUTION OF AUTOPHAGY RECEPTORS p62 AND NBR1
Terje Johansen, University of Tromsø, Norway
  11:40 Defending the host cytosol: Novel mechanisms for the selective autophagy of bacteria
Teresa Thurston, Imperial College, London, MRC-LMB, Cambridge,
London, UK
  12:00 SELECTIVITY FACTORS INVOLVED IN PEXOPHAGY
Suresh Subramani, University of California, San Diego, USA
  12:35

DIMERIZATION AND PHOSPHORYLATION OF NIX REGULATES ITS FUNCTION AS MITOPHAGY RECEPTOR
Ivana Novak, School of Medicine, University of Split, Split, Croatia

  12:55 Lunch plus free time
   
 
Session 7 - Selective Autophagy (cont.)
Chair: Ana Maria Cuervo, USA
15:00 – 18:35 (Shaked Hall)
  15:00 NOVEL MEDIATORS OF SELECTIVE AUTOPHAGY
Beth Levine, University of Texas Southwestern Medical Center, USA
  15:35 REGULATION OF STATIONARY PHASE MITOPHAGY IN S. CEREVISIAE
Hagai Abeliovich, The Hebrew University of Jerusalem, Israel
  16:10 C-CBL IS A SELECTIVE ADAPTOR FOR AUTOPHAGOSOMAL TARGETING OF SRC KINASE WHEN CELLULAR ADHESION IS LOST
Simon Wilkinson, Edinburgh Cancer Research UK Centre, University of Edinburgh, UK,
  16:30 Coffee
  17:00 MECHANISM OF UNCONVENTIONAL SECRETION BY SECRETORY AUTOPHAGOSOMES
Vivek Malhotra, Centre for Genomic Regulation (CRG), Spain
  17:35 A NEW AUTOPHAGY-RELATED CHECKPOINT IN THE DEGRADATION OF AN ERAD-M TARGET
Ami Navon, Weizmann Institute of Science, Rehovot, Israel
  17:55 REGULATION OF THE MEMBRANE TRAFFICKING DURING THE AUTOPHAGY HIJACKING BY YERSINIA PSEUDOTUBERCULOSIS
Frank Lafont, Institut Pasteur, Lille, France
  18:15

AUTOPHAGY IN A PROFESSIONAL SECRETORY CELL: BALANCING CELL DEATH AND ANTIBODY SECRETION
Niccolo Pengo, San Raffaele Scientific Institute, Milan, Italy

  19:00 Dinner
     
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