Autophagy in health and disease

Programme

Programme can be downloaded here

SUNDAY, 30 OCTOBER 2011
	Opening Session 18:00 – 20:00 (Shaked Hall)
	18:00	Welcome
	18:10	Keynote address THE CASPASE FAMILY AND THE DEATH-FOLD: AN EVOLUTIONARY CONSERVED ASSOCIATION ON GUARD AGAINST INTRACELLULAR AND EXTERNAL DANGERS David Wallach, Weizmann Institute of Science, Rehovot, Israel
	18:45	Discussion
	18:55	Keynote address EPITHELIAL CELL PLASTICITY, CANCER STEM CELLS AND AUTOPHAGY Patrice Codogno, INSERM U984, France
	19:30	Discussion
	19:45	Dinner

MONDAY, 31 OCTOBER 2011
	Session 1 - Autophagosomes Biogenesis Chair: David Rubinsztein, UK 08:30 – 10:20 (Shaked Hall)
	08:30	MOLECULAR DYNAMICS OF Atg PROTEINS DURING AUTOPHAGOSOME FORMATION IN YEAST Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
	09:05	THE MECHANISM OF PHAGOPHORE EXPANSION Daniel Klionsky, University of Michigan, USA
	09:40	MAMMALIAN ATG8s MEDIATE MEMBRANE FUSION Tomer Shpilka, Weizmann Institute of Science, Rehovot, Israel
	10:00	GAPs IN AUTOPHAGY: MULTIPLE Rab GAPs ARE IMPLICATED IN THE AUTOPHAGY PATHWAY BY DIRECT BINDING TO HUMAN ATG8 MODIFIERS Christian Behrends, Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt, Germany
	10:20	Coffee

	Session 1 - Autophagosomes Biogenesis (cont.) 10:40 – 12:15 (Shaked Hall)
	10:40	REGULATION OF AUTOPHAGOSOME COMPLETION Fulvio Reggiori, University Medical Centre Utrecht, The Netherlands
	11:15	betaA3/A1-CRYSTALLIN AS A NOVEL LYSOSOMAL COMPONENT REQUIRED BY THE RETINAL PIGMENTED EPITHELIAL (RPE) CELLS FOR AUTOPHAGY AND PHAGOCYTOSIS Debasish Sinha, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, USA
	11:35	PROTECTIVE ROLE OF AUTOPHAGY IN LIPID DYSFUNCTION CAUSED BY HEPATITIS C VIRUS Tiziana Vescovo, National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, Rome, Italy,
	11:55	A PHYSIOLOGICAL SYSTEM FOR SELECTIVE MITOCHONDRIAL DESTRUCTION IN DROSOPHILA Eli Arama, Weizmann Institute of Science, Rehovot, Israel
	12:15	Lunch plus free time

	Session 2 - Autophagosomes Biogenesis (cont.) Chair: Daniel Klionsky, USA 15:00 – 16:30 (Shaked Hall)
	15:00	REGULATION OF EARLY EVENTS IN AUTOPHAGOSOME BIOGENESIS David Rubinsztein, Cambridge University, UK
	15:35	BIOCHEMICAL AND MORPHOLOGICAL UNDERSTANDING OF MAMMALIAN Atg9 Sharon A. Tooze, London Research Institute, Cancer Research UK, UK
	16:10	STUDYING AUTOPHAGY THROUGH THE ROLE OF ULK1/2 AND MATG9, TWO ESSENTIAL AUTOPHAGY PROTEINS Eyal Kalie, Cancer Research UK, London, UK
	16:30	Coffee

	Session 2 - Autophagosomes Biogenesis (cont.) 17:00 – 18:30 (Shaked Hall)
	17:00	MAMMALIAN Atg PROTEINS IN AUTOPHAGOSOME FORMATION Noboru Mizushima, Tokyo Medical and Dental University, Japan
	17:35	INSIGHTS INTO MEMBRANE DYNAMICS IN AUTOPHAGY Tamotsu Yoshimori, Osaka University, Japan
	18:10	ROLE OF AUTOPHAGY AND GLUTAMATE DEHYDROGENASE IN THE CELLULAR METABOLISM OF TSC AND LAM Andrey Parkhitko, Brigham and Women’s Hospital and Harvard Medical School, Boston MA, USA
	19:00	Dinner
	20:00	Poster Session

TUESDAY, 1 NOVEMBER 2011
	Session 3 - Regulation of Autophagy Chair: Beth Levine, USA 08:30 – 12:55 (Shaked Hall)
	08:30	KINASE NETWORKS REGULATING AUTOPHAGY IN DROSOPHILA Thomas Neufeld, University of Minnesota, USA
	09:05	THE DISCOVERY OF MOLECULAR PATHWAYS CONTROLLING THE AUTOPHAGIC FLUX Adi Kimchi, Weizmann Institute of Science, Rehovot, Israel
	09:40	TNF-RESISTANT BREAST CANCER CELLS ACTIVATE HYPOXIA-LIKE CELLULAR RESPONSES LEADING TO THE AUTOPHAGY ACTIVATION. INVOLVEMENT OF SPHINGOSINE KINASE-1/SPHINGOSINE-1-PHOSPHATE PATHWAY Joanna Baginska, Public Research Center for Health (CRP-Santé), Luxembourg City, Luxembourg
	10:00	SCREENING FOR PHOSPHOINOSITIDE EFFECTORS OF AUTOPHAGY Anne Simonsen, University of Oslo, Norway
	10:35	Coffee
	11:05	FUNCTION AND REGULATION OF Atg1 KINASE IN AUTOPHAGY Claudine Kraft, Max F. Perutz Laboratories, University of Vienna, Austria
	11:40	EXPRESSION OF THE AUTOPHAGY GENE ALFY IS INHIBITED IN ACUTE MYLEOID LEUKEMIA AND ITS KNOCK-DOWN ATENUATES GRANULOCYTE DIFFERENTIATION Anna M. Schläfli, Department of Clinical Research, University of Bern, Switzerland
	12:00	DANCE WITH THE YEAST---ATGs and EPGs Hong Zhang, National Institute of Biological Sciences, China
	12:35	AUTOPHAGY IS REQUIRED FOR THE DIFFERENTIATION OF NEURAL STEM/PROGENITOR CELLS INTO NEURONS Patricia Boya, CSIC, Madrid, Spain and University of Rome "Tor Vergata", Rome, Italy
	12:55	Lunch plus free time

	Session 4 - Autophagy and Disease Chair: Noboru Mizushima, Japan 15:00 – 19:10
	15:00	AUTOPHAGY - AN EVOLVING IMMUNOLOGICAL PARADIGM Vojo Deretic, University of New Mexico, USA
	15:35	ROLE OF AUTOPHAGY AND AUTOPHAGY PROTEINS IN IMMUNITY AND INFLAMMATORY DISEASES Herbert W. Virgin IV, Washington University School of Medicine, USA
	16:10	PHOSPHORYLATION OF OPTINEURIN PROMOTES SALMONELLA AUTOPHAGY Ivan Dikic, Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt, Germany
	16:30	Coffee
	17:00	GENETIC ROUTES TO AUTOPHAGY FAILURE IN ALZHEIMER'S DISEASE Ralph A. Nixon, New York University Langone Medical Center; Nathan Kline Institute, USA
	17:35	REGULATED LC3 CONVERSION IN AUTOPHAGY BY RNF5 Ze'ev Ronai, Sanford-Burnham Medical Research Institute, USA
	18:10	Regulation of Autophagy in C. elegans by RNF-5, an E3 Ubiquitin Ligase Sharon Sheffy Levin, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
	18:30	THE POSSIBLE ROLE OF CYCLOPHILINS AS LINKERS OF AGING AND PROTEIN MISFOLDING TOXICITY Tziona Ben-Gedalya, Institute for Medical Research Israel-Canada (IMRIC), Hebrew University School of Medicine, Jerusalem, Israel
	18:50	JUN PROTEINS ARE STARVATION-CONTROLLED REGULATORS OF AUTOPHAGY Eitan Shaulian, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
	19:00	Dinner
	20:00	Poster Session

WEDNESDAY, 2 NOVEMBER 2011
	Session 5 - Autophagy, Cell Proliferation and Cell Death Chair: Ivan Dikic, Germany 08:30 – 10:40 (Shaked Hall)
	08:30	Ambra1 IS A RELAY MOLECULE IN THE CELL RESPONSE TO AUTOPHAGY INDUCTION Francesco Cecconi, University of Rome "Tor Vergata", Italy
	09:05	AUTOPHAGY: A STRESS-ADAPTIVE MECHANISM FOR A LONG LIFE WITHOUT CANCER Guido Kroemer, Institut Gustave Roussy, France
	09:40	AMBRA1 REGULATES THE LATE STAGES OF AUTOPHAGY BY MODULATING THE ACTIVITY OF THE LYSOSOMAL PROTEIN SPINSTER-1 Gian Maria Fimia, National Institute for Infectious Diseases IRCCS ‘L. Spallanzani’, Rome, Italy
	10:00	ATG16L1 DEFICIENCY CONFERS PROTECTION FROM PERSISTENT UROPATHOGENIC ESCHERICHIA COLI INFECTION IN VIVO Indira Mysorekar, Washington University School of Medicine, St. Louis, MO, USA
	10:20	EFFECTS OF DYNACTIN WITH A PATHOGENIC MUTATION FOR PERRY SYNDROME ON AUTOPHAGY Kei-Ichi Ishikawa, Juntendo University School of Medicine, Tokyo, Japan
	11:00	Coffee
	Afternoon	Jerusalem Tour and dinner

THURSDAY, 3 NOVEMBER 2011
	Session 6 - Selective Autophagy Chair: Adi Kimchi, Israel 08:30 – 12:55
	08:30	FUNCTIONAL CHARACTERIZATION OF Atg8-TARGETS IN AUTOPHAGY Matthias Peter, Swiss Federal Institute of Technology, Switzerland
	09:05	A PLANT-SPECIFIC Atg8-INTERACTING PROTEIN DEFINES A NOVEL STARVATION-INDUCED BODY DISTINCT FROM AUTOPHAGOSOMES Gad Galili, Weizmann Institute of Science, Israel
	09:40	THE AUTOPHAGY PROTEIN ATG12 ASSOCIATES WITH ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS TO PROMOTE MITOCHONDRIAL APOPTOSIS Assaf D. Rubinstein, Weizmann Institute of Science, Rehovot, Israel
	10:00	CHAPERONE-MEDIATED AUTOPHAGY IN THE REGULATION OF THE CELLULAR ENERGETIC BALANCE Ana Maria Cuervo, Albert Einstein College of Medicine, USA
	10:35	Coffee
	11:05	ROLES OF LIR MOTIF-MEDIATED INTERACTIONS IN AUTOPHAGY AND EVOLUTION OF AUTOPHAGY RECEPTORS p62 AND NBR1 Terje Johansen, University of Tromsø, Norway
	11:40	Defending the host cytosol: Novel mechanisms for the selective autophagy of bacteria Teresa Thurston, Imperial College, London, MRC-LMB, Cambridge, London, UK
	12:00	SELECTIVITY FACTORS INVOLVED IN PEXOPHAGY Suresh Subramani, University of California, San Diego, USA
	12:35	DIMERIZATION AND PHOSPHORYLATION OF NIX REGULATES ITS FUNCTION AS MITOPHAGY RECEPTOR Ivana Novak, School of Medicine, University of Split, Split, Croatia
	12:55	Lunch plus free time

	Session 7 - Selective Autophagy (cont.) Chair: Ana Maria Cuervo, USA 15:00 – 18:35 (Shaked Hall)
	15:00	NOVEL MEDIATORS OF SELECTIVE AUTOPHAGY Beth Levine, University of Texas Southwestern Medical Center, USA
	15:35	REGULATION OF STATIONARY PHASE MITOPHAGY IN S. CEREVISIAE Hagai Abeliovich, The Hebrew University of Jerusalem, Israel
	16:10	C-CBL IS A SELECTIVE ADAPTOR FOR AUTOPHAGOSOMAL TARGETING OF SRC KINASE WHEN CELLULAR ADHESION IS LOST Simon Wilkinson, Edinburgh Cancer Research UK Centre, University of Edinburgh, UK,
	16:30	Coffee
	17:00	MECHANISM OF UNCONVENTIONAL SECRETION BY SECRETORY AUTOPHAGOSOMES Vivek Malhotra, Centre for Genomic Regulation (CRG), Spain
	17:35	A NEW AUTOPHAGY-RELATED CHECKPOINT IN THE DEGRADATION OF AN ERAD-M TARGET Ami Navon, Weizmann Institute of Science, Rehovot, Israel
	17:55	REGULATION OF THE MEMBRANE TRAFFICKING DURING THE AUTOPHAGY HIJACKING BY YERSINIA PSEUDOTUBERCULOSIS Frank Lafont, Institut Pasteur, Lille, France
	18:15	AUTOPHAGY IN A PROFESSIONAL SECRETORY CELL: BALANCING CELL DEATH AND ANTIBODY SECRETION Niccolo Pengo, San Raffaele Scientific Institute, Milan, Italy
	19:00	Dinner

Conference Series

European Molecular Biology Organization

Autophagy in health and disease

Programme