Workshop

European Molecular Biology Organization

 

 

 

 

10 - 14 March | 2011 | Obergurgl | Austria

About the Workshop

AWARDED THE TITLE: 'EMBO Molecular Medicine Workshop 2011'

 

The aim of the workshop is to attract people that work in different fields of cell death research focusing on the relationship between cell death signalling and human diseases.


Findings on cell death regulation gained in animal models were shown to have general validity for the regulation of cell death signalling in humans.

 

For example, apoptosis, a genetically programmed pathway to remove superfluous or potentially harmful cells in the body of all metazoans is conserved in its fundaments from worm to men. Additional layers of cell death regulation, also found in humans, have been identified subsequently by studying cell death in different model organisms including yeast, C. elegans, drosophila or zebrafish.

 

Last but not least, Mus musculus has been proven to be a suitable model to study the relevance of cell death signalling in human pathologies such as cancer, autoimmunity and neurodegeneration and different key molecules of the apoptosis machinery are currently explored for their drugability in human diseases, some of them already well advanced in clinical trials.
download poster



A central theme of the event, therefore, will be to provide an update on recent findings relating to cell death signalling pathways that are currently targeted for the treatment of different human pathologies with a main focus on cancer and autoimmunity.


While apoptosis is a key mechanisms that is currently targeted at different levels, e.g. at the level of death receptor signalling, Bcl-2 family proteins or inhibitor of apoptosis proteins for the treatment of human disease, other cell death mechanisms such as autophagy or necroptosis are just in the process of being understood in molecular terms, opening new opportunities for therapeutic intervention.

Hence, a second focus of the workshop lies on alternative cell death mechanisms and their molecular basis and an emphasis will therefore also be given to define molecular interaction points between different modes of cell death events.

 

Last but not least, this workshop aims to strengthen the communication between basic researchers and those working on the translational aspects of cell death research as well as clinicians that are involved in early clinical trial using compounds that aim to target different cell death pathways.

 

 

We look forward to welcoming you to Obergurgl!

The Organisers

 

Co-Sponsors

 

 

European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany