Programme
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2pm-6pm |
Arrival & Registration |
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6.30pm |
Reception |
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7.30pm |
Dinner |
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9.00 - 9.15pm |
Opening Remarks by the Organizers |
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9.15 - 10.00pm |
Key Note Lecture: Carlo Croce (Ohio State University, US) "Causes and Consequences of microRNA Dysregulation in Cancer" CHAIR: Andreas Villunger |
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8.00-10am |
Session I "The p53 Family in Cell Death & Disease" CHAIR: Jerry Adams |
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8.00-8.30 |
EMBO YIP Lecture by Chris Marine, Ghent, BE "Dicer1 is a synthetic lethal partner of p53" |
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8.30-9.00 |
Daniel Murphy, Würzburg, DE "Too much of a good thing: Unrestrained TORC1 activity exposes Myc’s Achilles heel" |
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Ulrich Maurer, Freiburg, DE "Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53" |
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| 9.00-9.30 | Gerry Melino, Leicester, UK "p53 family, its involvement in neuronal development via miR-34a" |
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9.30-10.00 |
Laura Attardi, Stanford, CA, US "Unraveling p53’s Mechanisms of Action in vivo" |
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Coffee Break |
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10.30-11.00 |
Session II "The p53 family and beyond" CHAIR: Gerry Melino |
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J.P. Medema, Amsterdam, NL "Cancer stem cells resist therapy, but can be sensitized using HDAC inhibitors" |
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11.00-11.30 |
Claudia Manzl, Innsbruck, AT "Lack of the Chk1-suppressed alternative cell death pathway in murine cells" |
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Alexander Egle, Salzburg, AT Does p21/puma double deficiency mimic p53 loss? |
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afternoon |
Free Afternoon |
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4pm |
Coffee & Round Table Discussion |
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4:45-7pm |
Session III "Autophagy, Metabolism & Disease" CHAIR: Jan Paul Medema |
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4.45-5.15 |
Xin Lu, Oxford, UK "ASPP2: Tumour suppression through the control of polarity and autophagy" |
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5.15-6.00 |
Jennifer Martinez, Memphis, US "THE ROLE OF LC3-ASSOCIATED PHAGOCYTOSIS IN DEAD CELL CLEARANCE" |
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Inês Pimenta de Castro, Leicester, UK "Genetic analysis of mitochondrial protein misfolding " |
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Cristina Munoz-Pinedo, Barcelona, ES "Mechanisms of tumor cell death induced by inhibition of glucose metabolism" |
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6.00-6.30 |
Hamsa Puthalakath, Melbourne, AU "Molecular Mechanisms of cAMP induced Apoptosis" |
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Jochen Prehn, Dublin, IE "Cell death signaling by the energy sensor AMPK involves BH3 Only Proteins Bim and Bmf" |
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| 6.30-7.00 | Seamus Martin, Dublin, IE "Oncogene-induced autophagic cell death is regulated by Bcl-2 family proteins" |
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Dinner |
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8.30-10.00pm |
Poster Session A (odd numbers) |
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8.00-10am |
Session IV "The Bcl-2 Family in Leukocyte Development & Immunity" CHAIR: Thomi Brunner |
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8.00-8.30 |
Andreas Strasser, Melbourne, AU "The role of BH3-only proteins in lymphocyte development" |
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| 8.30-9.00 | Eric Eldering, Amsterdam, NL Exploring the route from co-stimulation to apoptosis in determining diversity of an immune response |
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Eleonora Ottina, Innsbruck, AT "Exploring the Role of A1/Bfl1 in leukocyte biology" |
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9.00-9.30 |
Suzanne Kirschnek, Freiburg, DE "Molecular analysis of neutrophil apoptosis reveals a strong role for Noxa" |
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Denise Tischner, Innsbruck, AT "Dual roles for TGFß in iTreg cell homeostasis" |
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| 9.30-10.00 | Miriam Erlacher, Freiburg, DE "Lack of the BH3-only proteins in stem cells facilitates reconstitution of haematopoiesis" |
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Jamie Lopez, Melbourne, AU "A Window Of Opportunity: The Mechanism of Perforin and Granzyme Mediated Cell Death" |
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Coffee Break |
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10.30-11.30 |
Session V "The Bcl2 Family in Cancer" CHAIR: Christoph Borner |
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10.30-11.00 |
Suzanne Cory, Melbourne, AUS "IMPACT OF BCL-2 AND MCL-1 IN CANCER DEVELOPMENT AND CANCER TREATMENT" |
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11.00-11.30 |
Martin Schuler, Essen, DE "Basis of anti-EGFR antibody-dependent therapy and its intersection with oncogenic RAS" |
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Arnon Kater, Amsterdam, NL "TNF family proteins cause drug resistance via Bcl-2 family proteins in CLL" |
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| 11.30-12.00 | Antony Letai, Harvard, US "Why chemotherapy works - differential mitochondrial apoptotic priming that can be measured by BH3 profiling" |
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afternoon |
Free Afternoon |
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4pm |
Coffee & Round Table Discussion |
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5.00-7.00 pm |
Session VI "Cell Death Signaling I" CHAIR: Jochen Prehn |
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4.45-5.15 pm |
Doug Green, Memphis, US "P53, Mitochondria, and Apoptosis: Give and Take in the BCL-2 Family" |
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| 5.15-6.00 | Ehsan Pourkarimi, Dundee, UK "The localization of CED-9/Bcl2 and CED-4/Apaf-1 is not consistent with the accepted model for apoptosis induction" |
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Thomas Kaufmann, Bern, CH "Characterization of BOK-deficient mice" |
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Peter Czabotar, Melbourne, AU "A mutation to Bax that disrupts binding to pro-survival proteins and promotes apoptosis" |
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| 6.00-6.30 pm | El Maadidi Souhayla, Freiburg, DE "Semliki Forest Virus can use an alternative pathway to cell death in the absence of Bax/Bak" |
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Doug Fairlie "Discovery and characterization of the cell death machinery in platyhelminthes" |
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6.30-7.00 pm |
Guy Salvesen, SanDiego, US "Caspases and their Homologues in Cell Signaling" |
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Dinner |
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8.30-10.00pm |
Poster Session B (even numbers) |
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| 13th March | ||
8.00-10am |
Session VII "Cell Death Signaling II" CHAIR: Marion MacFarlane |
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8.00-8.30 |
Peter Vandenabeele, Ghent, BE "In vitro and in vivo regulation of TNF-induced necroptosis" |
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8.30-9.00 |
Andrew Oberst, Memphis, US "Catalytic Activity of the Caspase-8-FLIPL Complex Protects Cells from RIPK3-Dependent Necrosis" |
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Martin Leverkus, Heidelberg, DE "cIAPs block TLR3-mediated cell death by interference with Ripoptosome formation" |
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9.00-9.30 |
Maria Andree, Köln, DE "Non-apoptotic antagonization of XIAP by mitochondrial SMAC interrupts cell-autonomous pro-inflammatory signaling" |
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Laura Dickens, Leicester, UK "Proteomic characterization of the native TRAIL DISC" |
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9.30-10.00: |
Inna Lavrik, Heidelberg, DE "Life/death decisions at CD95: is it only about caspase-8 and c-FLIP" |
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Coffee Break |
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10.30-12.30 |
Session VIII "IAP-proteins in development and disease" CHAIR: Inna Lavrik |
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10.30-11.00 |
Pascal Meier, London, UK "IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer" |
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11.00-11.30 |
Mads Gyrd-Hansen, Copenhagen, DK "X-linked Inhibitor of Apoptosis (XIAP) in NOD2-dependent innate immune signalling" |
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Philip Jost, Munich, DE "XIAP mediates NOD2-dependent NF-kB activation in macrophages" |
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11.30-12.00 |
John Silke, Melbourne, AU "Surfing with the IAPs, sucked in by the RIP" |
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afternoon |
Social Event: 3rd APOPTOSIS CUP |
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| 4pm | Coffee & Round Table Discussion | |
Session IX "Inflammation & Autoimmunity" CHAIR: Andreas Strasser |
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| 5.00-5.30 pm | Henning Walczak, London, UK "Linear ubiquitination prevents inflammation and regulates immune signalling " |
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| 5.30-6.00 pm | David Wallach, Revhot, IL |
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| 6.00-7.00 pm | Key Note: Shigekazu Nagata; Kyoto, Japan “Apoptosis & Autoimmunity” |
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Dinner |
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Evening |
Social Evening "Apoptosis-CUP Award Ceremony" |
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| 7.30-9.30 | Breakfast - Departure | |
