Conference Series

European Molecular Biology Organization

 

CENTROSOMES &

SPINDLE POLE BODIES

2 - 6 Oct 2011 | Barcelona| Spain

About the Conference Series

Registration & abstract submission deadline: 12th August, 2011.

The principal theme is to understand the function of microtubule organizing centers that are known as centrosomes in animal cells and spindle pole bodies in fungi and basal bodies in many protozoa. They are organelles of with a wide diversity of structure that organize microtubule arrays.

This diversity in structure reflects the distinct functional demands within very different organisms. Despite these marked structural differences a common functions in microtubule and cell cycle organization are observed. Thus, principles established in one system are invariably directly relevant to seemingly different structures in other organisms. As the biology and technology applicable to each system varies, each system lends itself to the discovery of distinct aspect of MTOC biology.

 

In addition to interspecies variation, MTOCs perform distinct functions at different stages of the cell cycle as illustrated by the alterations in centrosome function as human cells transit the cell cycle. During mitosis, centrosomes/spindle poles participate in both the organization and orientation of the mitotic spindle and thus, the arrangement and segregation of chromosomes. Centrosomes assemble astral microtubules that are important for focusing non-centrosomal microtubules at spindle poles and for orientating the mitotic spindle within cells.

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Control of spindle orientation is essential for defining the plane of cell division during the symmetric and asymmetric divisions of stem cells and epithelial cells. During interphase centrosomes are responsible for organizing the structure of the cell and generating the sensory primary cilium.

It is becoming increasingly apparent that MTOCs do not just organize the cytoskeleton but also act as co-ordination centers for cross talk between the signal transduction events that regulate cell cycle progression through checkpoints. Thus DNA damage signaling and cytokinesis are both co-ordinated by the MTOC.

It is also becoming i apparent that defects in these interphase and cell cycle control functions of MTOCs lead to disease states such as microcephaly, retinopathies, and kidney disease.Thus, centrosomes also play important roles in genome stability development and disease.

The conference will address the key areas of

 

  • microtubule nucleation
  • MTOC structure
  • MTOC duplication
  • MTOC participation in cell cycle controls
  • MTOC function and disease
  • MTOC differentiation during development and cell cycle progression

 

We look forward to welcoming you to Barcelona

The Organisers


Co-Sponsors

   
 
   
   

 

 

European Molecular Biology Organization | Meyerhofstrasse 1 | 69117 Heidelberg | Germany