European Molecular Biology Organization




12 - 14 October| 2011 | IGBMC | Strasbourg | France

About the Workshop


*** LATEST UPDATES: (4th October)

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Histone variants have emerged as key players in regulating chromatin structure and dynamics. This workshop will cover broad aspects of the biology and structural variations of histones and their impact in cellular processes.


Topics will include:

structure of histone variants and their mode of incorporation
   into chromatin
genome organization

responses to the environment

reprogramming and stem cells

gametogenesis and reproduction


Epigenetic mechanisms are key for gene regulation and regulate cell plasticity, cell differentiation and development. In the recent years, epigenetics has become a main and extremely productive field in the life sciences. In general terms, epigenetic mechanisms involve:


- the packing of the DNA
- the dynamics of eu- and hetero- chromatin compartments and
   chromatin components
- covalent modifications of DNA and histones.

  rollover thumbnails for larger images

The building block of the chromatin is the nucleosome, which is composed of an octamer of two copies of each of the core histones wrapped by DNA. Apart from the major core histones, whose synthesis and incorporation into chromatin is linked to the S phase of the cell cycle, histone ʻvariantsʼ are synthesized and incorporated into chromatin independently of DNA replication.

These ʻreplacementʼ histones confer distinct properties to nucleosomes, and appear to be involved in important epigenetic processes such as X-inactivation. Recent progress has made clear that histone variants have a key role in regulating chromatin structure regulating development, reprogramming of germ cells and parasite infectiousness.

The workshop will focus on the structural and functional impacts of variations in histone sequence. Specialists of chromatin structure and transcription will meet with developmental biologists and physiologists to share their common interest on histone variants in yeast, plants and animals. The participants will have the opportunity to present and discuss their work during the poster sessions. An important number of abstracts will also be chosen for short talks.

This is the first meeting entirely dedicated to this important emerging topic.

We look forward to welcoming you to Strasbourgl!
The Organisers
click image above to view/download poster







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