About the Practical Course
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The intention of the course is to provide practical training in important aspects of using solution state NMR spectroscopy for studying the structure, dynamics and function of biomolecular macromolecules. The emphasis will be on setting up experiments on the spectrometer (optimizing parameters, pulse programs), on processing and analyzing the NMR data and on structure calculations in a hands-on fashion.
It is impossible to teach all the necessary theoretical background of modern NMR experiments in a few days. Therefore, the course is aimed at PhD students and postdocs who have some working knowledge of NMR theory, i.e. product operator formalism, and who understand the basic principles of NMR pulse sequences. Possible candidates should have the level of knowledge of students that have participated in a past "Advanced NMR" EMBO lecture course on NMR theory organized by Boelens, Oschkinat and Griesinger.
Topics
• Pulse sequences: theory, design, practical set-up and use
• Multidimensional data processing and data analysis
• Relaxation: theory, experiments, data analysis
• Residual dipolar and J-couplings: theory, experiments, data analysis
• Structure calculation and validation: proteins and RNA
• Protein-ligand interactions
• High molecular weight systems, TROSY, CRINEPT, etc.
• Advanced/fast data acquisitionand processing
The programme and further details for the course will be updated at http://www.bnmrz.org/embo2011.
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| We look forward to welcoming you to Garching! The Organisers |
