Workshop

European Molecular Biology Organization

 

Retinoids 2011

22 – 24 September, 2011 | Strasbourg | France

Programme

 

Wednesday, September 21


 

14:00-19:00

Registration and welcome drink

 

 

 

Thursday, September 22


 

08:00-17:00

Registration

 

09:00-09:10

Introduction by the organizers

 

09:10-10:10

DNA repeats, non-coding RNAs, Nuclear Architecture, and Non-Histone Modifications Integration of Transcriptional Regulatory Programs

M.G Rosenfeld: keynote lecture

 

10:10-10:30

Coffee break

 

 

 

 

SESSION I – Nuclear Retinoid Receptors: structure and evolution

 

10:30-11:10

Allosteric control of cofactor binding to nuclear hormone receptors: RARs provide the structural basis for a molecular mechanism

D. Moras

 

11:10-11:50

Evolution of retinoic acid and its signalling pathway

V. Laudet

 

11:50-12:30

Transcriptional regulation through retinoid receptors heterodimers and coregulator exchange: molecular and structural basis

W. Bourguet

 

12:30-15:20

Lunch/Poster session

 

 

 

 

SESSION II – Nuclear Retinoid Receptors-mediated transcription

 

15:20-16:00

Diversity in the sequence and topology of natural retinoic acid receptor occupied sites

I. Davidson

 

16:00-16:40

Retinoic Acid Receptors in Acute Myeloid Leukemia: a systems biology view

H. Stunnenberg

 

16:40-17:00

Molecular mechanism of RARg-vinexinb interaction and its modulation by serine phosphorylation

B. Kieffer

 

17:00-17:30

Coffee break

 

17:30-18:10

An unexpected role of the DNA repair factors in the transactivation by RAR

J.M. Egly

 

18:10-18:50

Epigenetic regulation of Cellular Retinoic Acid Binding Protein I gene: action of RIP140

LN Wei

 

18:50-19:10

Epigenetic basis of the retinoic acid paradox

N. Sacchi

 

19:30

Dinner

 

 

 

Friday, September 23


 

SESSION III – Retinoids in stem cells biology and development

 

09:00-9:40

Retinoic acid and embryonic symmetry

O. Pourquie

 

09:40-10:20

Retinoid signalling during neural differentiation in embryos and ES cells

K. Storey

 

10:20-10:40

Nuclear retinoic acid receptors: cross-talk between non genomic (activation of kinase cascades) and genomic effects

A. Piskunov

 

10:40-11:00

Coffee break

 

11:00-11:40

Regulation of retinoic acid synthesis during embryogenesis and nervous system development

P. Dollé

 

11:40-12:00

Control of FGF somite wavefront by retinoic acid signaling to epiblast progenitor cells

G. Duester

 

12:00-12:40

Control of retinoic acid synthesis and signaling in luminal breast cancer cells.

S. Mader

 

12:40-14:30

Lunch

 

14:30-19:30

Free afternoon (visit of Strasbourg)

 

19:30

Gala Dinner

 

 

 

Saturday, September 24


 

9:00-10:00

Positive and negative control of transcription by nuclear receptors

P. Chambon (Plenary lecture)

 

10:00-10:20

Coffee break

 

 

 

 

SESSION IV – Retinoids metabolism and signaling

 

10:20-11:00

Hepatic Retinoid: Storage and Metabolism:  Biology and Pathobiology 

W. Blaner

 

11:00-11:20

RA biosynthesis defects in cancer

M.A. Kane

 

11:20-12:00

Signalling by vitamin A

N. Noy

 

12:00-12:40

retinoic acid its nuclear receptors in male germ cell differentiation

N. Ghyselinck

 

12:40-14:40

Lunch/Poster session

 

 

 

 

SESSION V – Retinoids in cancer

 

14:40-15:20

Retinoic acid dependent microRNA and epigenetic networks in leukemia

C. Nervi

 

15:20-15:40

Retinoic acid and tamoxifen resistance in human breast cancer stem cells.

M. Vivanco

 

15:40-16:20

Retinoic acid and its receptors as cancer promoters

V. Giguere

  16:20-16:40

Targeted epigenetic reprograming of RARs and sensitivity to isotype-specific agonists in breast cancer

E.F. Farias

 

16:40-17:00

Coffee break

 

17:00-17:40

Restoring RAR promoter permissiveness

C. Chomienne

 

17:40-18:00

Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells

E. Segal-Bendirjian

 

18:00-18:40

Molecular basis for APL cure by retinoic acid and arsenic

H. de Thé

 

18:40-19:00

Conclusion of the meeting

 

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