Conference Series

 

 

The Physiology of the
endoplasmic reticulum (ER):

Function and Dysfunction

 

 

 

 

 

 



15 - 19 October, 2012 |Caldes de Malavella| Spain

Programme


Download Programme: (word.doc)  
   
Monday 15th | Tuesday 16th | Wednesday 17th | Thursday 18th | Friday 19th  
     

Monday October 15

 

 

13:00-18:30

Registration

 

18:30-19:00

Welcome

 

19:00-20:00

Keynote Lecture: Jonathan Weissman, UCSF

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

 

20:00-22:00

Welcome Dinner

 

 

 

 

Tuesday October 16

 

 

9:00-11:00

Session 1: Translocation and Membrane Targeting

Chair: Peter Walter

 

09:00

Robert Keenan
Tail-anchored Membrane Protein Biogenesis

 

09:25

William Skach
Dynamic Regulation of ER Translocon Structure During Nascent Chain Translocation                 

 

09:50

Stephen High
Tail-anchored Membrane Proteins & Ubiquitin: Strange Bedfellows?

 

10:15

Irmgard Sinning
Mechanisms of Protein Insertion by the SRP and GET Systems        

 

10:40

Tslil Ast

Uncovering the Cytosolic Chaperoning and Targeting Factors of an SRP Independent Protein Family

 

11:00-11:30

Coffee break

11:30-13:30

Session 2: Folding and Misfolding in the ER

Chair: David Ron

 

11:30

Anne Bertolotti
Surviving Proteasome Inhibition

 

11:55

Maurizio Molinari
ERAD Tuning: Setting The Luminal Concentration Of ERAD Factors By Regulating Their Segregation and Turnover

 

12:20

Ineke Braakman
Protein Folding In The ER

 

12:45

Johannes Buchner
Chaperone-Assisted Quality Control And Secretion Of Antibodies

 

13:10

Karin Romisch

Identification Of New Mutants In The Sec Complex Affecting ERAD

 

13:30-15:00

Lunch

 

15:00-17:00

Poster Session (Posters 1 - 35)

 

17:00-19:00

Session 3: Post-Translational Modifications

Chair: Maya Schuldiner

 

17:00

Chiara Zurzolo
 GPI-Anchored Proteins Sorting To The Apical Surface Of Polarized Epithelial Cells Drives Their Clustered Organization And Their Functional State

 

17:25

Sabine Strahl

Interplay of Protein O-Mannosylation and N-Glycosylation at the Yeast Endoplasmic Reticulum

 

17:50

Gert Bolt
Intracellular Processing and Secretion of Coagulation Factor VII

 

18:15

Lars Ellgaard

Effects Of Manipulating Pathways For Disulfide-Bond Formation In The Mammalian ER

 

18:40

Asvin Lakkaraju

Unconventional Role Of Calnexin In The Control Of Apoptosis

 

19:00-20:30

Dinner

20:30 onwards

Poster Session (Posters 1 - 35)

 

     

Wednesday October 17

 

 

9:00-11:00

Session 4: ER Stress Responses I

Chair: David Ron

 

09:00

Davis Ng

A Composite Stress Response Buffers Lipid Disequilibrium By Remodeling The Protein Homeostasis Network     

 

09:25

Ala Trusina
How Does ER Adapt To Rapidly Fluctuating Stresses: Quantitative Modeling Approach

 

09:50-

Federica Brandizzi
Unfolded Protein Response In The Model Species Arabidopsis Thaliana     

 

10:15

Eelco Van Anken
Selective Engagement Of ER Stress Sensors By Antibody Subunit

 
10:40

Carmela Sidrauski
Inhibitor Of The PERK Branch Of The Unfolded Protein Response Makes Cells Insensitive To The Effects Of eIF2α Phosphorylation

 

11:00 - 11:30

Coffee break

 

11:30-13:00

Session 5: ER Stress Responses II/Contact Sites
Chair: Peter Walter

 

11:30

Kenji Kohno

Ribosomal Stalling Promotes XBP1u mRNA Splicing upon ER Stress

 

11:55

Menachem Rubinstein

 C/EBPbeta Attenuates ER Stress-Triggered Cell Death By Inducing Microsomal Glutathione S Transferase 1 (MGST1)

 

12:10

Adabella van der Zand

 The ER as a Platform for Peroxisome Biogenesis

 

12:35

Gia Voeltz
Role Of ER Structure And Dynamics At Organelle Contact Sites

 

13:00-14:00

Lunch

13:00 Tour to Dali museum (with packed lunch)  

14:00

Tou to Vineyard / Golf activities

 

17:00-19:00

Session 6: Trafficking - I

Chair: Blanche Schwappach

 

17:00

Randy Schekman
Autophagic Lipidation Of LC3 Organized On An Isolated ERGIC-Enriched Membrane Fraction

 

17:25

Frederick Hughson
Multisubunit Machines In Intracellular Trafficking

 

17:50

Koret Hirschberg
How To Enter ER Exit Sites?

 

18:15

Christoph Kaether

A Microscope-Based High-Throughput Screen Identifies Novel Compounds Interfering With Notch Trafficking/Processing

 

18:40

Colin Adrain
Role of iRhoms in the Early Secretory Pathway

 

19:00-20:30

Dinner

 

20:30 onwards

Poster Session (Posters 36 - 70)

 

     

Thursday October 18

 

 

9:00-11:00

Session 7: Trafficking - II

Chair: Blanche Schwappach

 

09:00

Paul Lehner

 Identifying Novel ERAD Ubiquitin E3 Ligases In The Regulation Of MHC Class I Molecules

 

09:25

Elizabeth Conibear 

Regulating The Intracellular Retention Of Chs3 At The ER And Golgi

 

09:50

Liz Miller

Membrane Rigidity, Vesicle Formation And The Protein Quality Control Checkpoint          

 

10:15

Chris Hawes 
Pull It, Stretch It: In Vivo Manipulation Of Plant ER With Laser Tweezers

 

10:40

Boaz Tirosh

Functional Overlap Between The mTor And The Unfolded Protein Response In Promoting Protein Secretion

 

11:00-11:30

Coffee break

 

11:30-13:30

Session 8: Ion Homeostasis

Chair: Blanche Schwappach

 

11:30

Karin Schumacher

The V-ATPase - Assembly, Quality Control And ER-Export

 

11:55

Richard Lewis
Mechanisms Of Calcium Trafficking At ER-Plasma Membrane Contact Sites

 

12:20

Ingo Greger
AMPA Receptor Subunit Assembly – Rules And Regulators

 

12:55

Roberto Sitia
Redox Signaling In The Early Secretory Compartment: Generation And Transport Of Hydrogen Peroxide Across Membranes

 
13:20

Christian Appenzeller-Herzog
Endoplasmic Reticulum: Reduced And Oxidized Glutathione Revisited

 

13:30-15:00

Lunch Break

15:00-18:00

Poster Session (Posters 36 - 71)

 

18:00 - 19:30

Special Session with Antibodypedia

Improving antibody annotation
 

20:00 - Onwards

Banquet

 

     

Friday October 19

 

 

09:00-11:00

Session 9: ER in Development and Disease

Chair: David Ron

 

09:00-

Hyung Don Ryoo

Regulators Of Mutant Rhodopsin-Associated Toxicity

 

9:25

Lisa Swanton

 Torsina And The Molecular Basis Of Torsion Dystonia

 

09:50

Gareth Lavery

Hexose-6-Phoshate Dehydrogenase And The Sarcoplasmic Reticulum
In Skeletal Muscle Homeostasis

 

10:15

Marius Lemberg
Sampling The Membrane: Function Of Intramembrane Proteases In ER Protein Homeostasis

 

10:40

Maurizio D’antonio

Modulation Of ER Homeostasis As A Therapeutic Target In CMT Hereditary Neuropathies

 

11:00-11:30

Coffee break

 

11:30-12:45

Session 10: Lipid Biosynthesis

Chair: Maya Schuldiner

 

11:30

Eva Herker
Diacylglycerol Acyltransferase 1 Acts As A Host Factor For Hepatitis C Virus Replication

 

11:55

Günther Daum
Endoplasmic Reticulum And Lipid Droplets Of The Yeast Interact During Synthesis, Storage And Mobilization Of Non-Polar Lipids

 

12:20

Robert Farese
The ER And Lipid Droplets

 

12:45

Romain Volmer
Endoplasmic Reticulum Lipid Bilayer Acyl Chain Saturation Directly Tunes The Unfolded Protein Response

 

13:00 - 13:45

Closing Lecture:  Howard Riezman

Systematic Lipidomic Analysis of Yeast Mutants Reveals Novel Regulation of Lipid Homeostasis

 

13:45

Lunch and Departure