ABOUT THE LECTURE COURSE

The main objective of this EMBO Global Exchange Lecture Course is to teach the young PhD students and postdocs from all areas of biology the methods applicable to study biological macromolecules in solution. We aim at a comprehensive coverage of the field including the major structural and biophysical techniques employed for the characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding and stability, protein-protein and enzymatic mechanisms.

The major task for structural biology is to elucidate the structural mechanisms behind the functional behavior of the system. Structural methods applicable to solutions offer the unique opportunity to carry out structural and functional studies on biological macromolecules under physiologically relevant conditions. Fully exploiting this opportunity allows one to extract the maximum amount of information and to relate the structural results to the function of the system.

The main objective of the Course is to teach the young PhD students and postdocs from all areas of biology the methods applicable to study biological macromolecules in solution. We aim at a comprehensive coverage of the field including the major structural and biophysical techniques employed for the characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding and stability, protein-protein and protein-ligand interactions and enzymatic mechanisms.

The Course will include lectures on small-angle X-ray and neutron scattering (SAXS/SANS), nuclear magnetic resonance (NMR), analytical ultracentrifugation (AUC) and spectroscopic approaches. Bioinformatic tools to analyze protein-protein interactions will also be considered, and the joint use of the solution characterization methods with the major non-solution structural techniques, macromolecular crystallography (MX), electron microscopy (EM), mass spectrometry (MS) and with the in situ methods will be covered. Special attention will be paid to interdisciplinary approaches, where the synergistic use of complementary techniques leads to a comprehensive description of macromolecular systems.

 

VENUE

 

   

Centre for Cellular and Molecular Biology (CCMB)
Habsiguda, Uppal Road
Hyderabad 500007
AP, India - read more

We look forward to welcoming you
to Hyderabad!

poster

 

SPONSORS