ABOUT THE CONFERENCE

The overall theme of this conference series is protein homeostasis - the regulation of protein folding in the cell - and the mechanisms and consequences of protein misfolding and aggregation caused by cell stress, disease and ageing.

For this series, we have included a new focus on biogenesis and folding of membrane proteins and the programme will reflect recent progress in the study of aggregation in vivo with focus on studies of sub-cellular organelles, the endocytic pathway and autophagy.

The overall theme of this conference series is protein homeostasis - the regulation of protein folding in the cell - and the mechanisms and consequences of protein misfolding and aggregation caused by cell stress, disease and ageing. This field builds on the parallel efforts of basic biophysicists who study the principles of protein folding and mechanisms of chaperone machines, alongside biochemists and cell biologists who study the actions of chaperone networks and turnover of aggregates in cells and tissues, as well as molecular biologists who study how genetic regulation determines the balance between the stress response, cell proliferation and ageing. The pathologists who deal with major diseases of protein misfolding, such as Alzheimers, Parkinsons and the prion diseases, are increasingly part of this community. These and numerous other serious conditions are associated with deposition of protein aggregates in cells and tissues. The European chaperone meetings have provided a focus for lively discussion and interaction between scientists interested in these different aspects of protein folding, chaperone biology and pathology.

For this series, we have included a new focus on biogenesis and folding of membrane proteins. The interaction of membrane proteins with the chaperone systems is much less well understood and we hope to initiate new discussions in the field by bringing in several leading experts in membrane protein folding and in protein translocation across membranes. In addition, the programme will reflect recent progress in the study of aggregation in vivo by including a greater focus on studies of sub-cellular organelles, the endocytic pathway and autophagy. These topics will be covered in addition to the continuing emphasis on mechanisms of chaperone machines and the stress response, the relationship between protein translation and folding and protein aggregation.

Our objectives are to bring together scientists from research students through to leading established investigators for stimulating talks and ample discussion in a comfortable, isolated location that keeps all participants together and fosters relaxed, informal contacts. Participants’ interests range from single molecule mechanics, through structural and theoretical studies to biochemical and in vivo analyses at the organelle and cell levels, to molecular and cellular pathologists seeking to understand and develop therapies for the intractable, degenerative diseases of protein misfolding.

 

VENUE

 

   

Hotel Flamingo Resort
Santa Margherita di Pula, 09010

Sardinia, Italy

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We look forward to welcoming you
to Santa Margherita di Pula!

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