ABOUT THE CONFERENCE
The DNA damage response (DDR) is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR is affected by – and in turn impacts on – myriad cellular components and processes, which include chromatin structure, DNA replication, telomeres, cell growth and cell-cycle status. Failure of the DDR or associated events causes genomic instability, an underlining cause of several human syndromes and also associated with various age-related diseases, particularly cancer. Notably, DNA damaging agents are also used in cancer therapy and drugs targeting DNA damage response enzymes are exhibiting an exciting potential as new anti-cancer agents.
The conference we propose will cover topics including:
- DNA damage detection and signalling
- Pathways of DNA repair
- DNA replication
- DNA damage response and the normal cell physiology
- Chromatin structure
- Ubiquitylation and related processes
- Ageing, disease and therapeutic applications.