ABOUT THE workshop

In 1994 a seminal paper from John Dick's group (Lapidot et al., Nature 367:645–648) provided the first compelling evidence that only a relatively minor subset of human acute myeloid leukaemia cells displayed leukaemia-initiating properties when xenotransplanted in immunocompromised animals, whereas the majority of the leukaemic cell population did not show significant leukaemogenic potential. These findings, confirmed by numerous subsequent studies that extended the concept of cancer stem cells to several solid malignancies, prompted an extraordinary effort to elucidate the biology of these cells, identify specific markers, characterise their regulatory mechanisms and discover novel therapeutic agents for their eradication. Two decades later, an impressive wealth of information has been gained on cancer stem cells but numerous basic questions remain open. The aim of this EMBO Workshop is to bring together several of the most distinguished scholars in the field, as well as junior investigators, post-doctoral fellows and students active in cancer stem cell research, for a critical assessment of the progress thus far made in the understanding of the biology of cancer stem cells, of their clinical relevance and prognostic value, and in the identification of effective strategies for their selective targeting.

In addition to the invited speakers’ presentations, 20 abstracts will be selected for oral presentation. Two poster-viewing sessions are planned, but the posters will be displayed throughout the workshop. Meet-the-expert sessions will be held at breakfast time to allow the informal discussion of topics of particular interest. The main venue of the workshop will be the Estella Club Hotel-Residence, an attractive seaside resort located near Catanzaro on the Ionian coast of Calabria, where all participants will be accommodated in a self-contained, comfortable environment that will facilitate the interactions. The final session will be held in the Auditorium of the University of Catanzaro Magna Græcia. The workshop venue is within convenient distance from the international airport of Lamezia Terme (SUF) and the Lamezia Terme Centrale railway station. Shuttle service between the airport/train station and the Workshop venue will be made available.

Topics include:

- Advances and controversies in cancer stem cell research
- New technologies, experimental systems and approaches to study and target cancer stem cells
- Regulatory mechanisms and targeting options
- Role of microenvironment in cancer development, maintenance and dissemination
- Circulating tumour cells and metastases

Abstract submission deadlines has been extended until: 15 July 2014.





Villaggio Guglielmo is an attractive seaside resort on the Gulf of Squillace on Ionian coast of Calabria, near Catanzaro, Italy

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