The endoplasmic reticulum (ER) is an architecturally complex intracellular organelle bordered by a single continuous membrane. It serves as the entry site into the secretory pathway allowing folding and maturation of the vast majority of secreted and membrane-bound proteins. In addition, the ER carries the main load of cellular lipid biosynthesis. The ER is also extremely important in regulating homeostasis of Ca2+ and actively maintains gradients for various small molecules across its membrane. 
Due to its central role the ER also serves as the main communication hub of cellular organelles coordinating many cellular functions through interorganellar- or membrane- contact sites (MCS) with every other organelle in the cell. The spectrum of functions as well as the complexity of the regulation of such MCS are now being investigated extensively and will be a focus of this third meeting in the series.

Despite an enormous body of work that is being performed on this organelle and its various functions every year, there is no conference that is dedicated to understanding its function and the way it regulates all of its different roles in parallel. The objective of this EMBO Conference series is to bring together people from all the different disciplines of ER research to try and integrate the knowledge that has accumulated in the different fields and allow the emergence of a new and more holistic understanding of ER functions. In addition, the conference organizers objective is to create an environment that will be supportive of discussions and the emergence of new collaborations. Moreover, this event aims for young scientists to think and formulate the major problems in the field and to advance their research capabilities.



Melia Golf Vichy Catalan,



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