ABOUT THE LECTURE COURSE

The main objective of this EMBO Global Exchange Lecture Course is to teach the young PhD students and postdocs from all areas of biology the methods applicable to study biological macromolecules in solution. We aim at a comprehensive coverage of the field including the major structural and biophysical techniques employed for the characterization of high and low resolution structure and structural transitions, assembly processes, protein folding and stability, macromolecular interactions and enzymatic mechanisms.

Structural methods applicable to solutions offer the unique opportunity to carry out structural and functional studies on biological macromolecules under virtually identical conditions. Fully exploiting this opportunity allows one to extract the maximum amount of biologically meaningful information and to relate the structural results to the function of the system.
The main objective of the Course is to teach the Brazilian PhD students and postdocs the methods to study biological macromolecules in solution. We aim at a comprehensive coverage of the major structural and biophysical techniques employed for characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding, stability, interactions and enzymatic mechanisms.
The Course will include lectures on small-angle X-ray and neutron scattering (SAXS/SANS), nuclear magnetic resonance (NMR), static and dynamic light scattering (SLS/DLS), analytical ultracentrifugation (AUC), differential and isothermal calorimetry (DSC/ITC) and spectroscopic approaches. Bioinformatic tools to analyze protein-protein interactions will be considered, and the joint use of the solution characterization methods with the major non-solution structural techniques including macromolecular crystallography (MX) and electron microscopy (EM) will be covered. Special attention will be paid to interdisciplinary approaches, where the synergistic use of complementary techniques leads to a comprehensive description of macromolecular systems.

 

VENUE

 

   

Sao Paulo is the largest city in Brazil, centrally located and well connected by air (both national and international), bus, metro and taxis connections enabling and easy access for participants to reach the IFUSP. read more

We look forward to welcoming you
to São Paulo!

poster

Meet other participants on facebook

 

SPONSORS