ABOUT THE Global exchange lecture course
Non-coding small RNAs (sRNAs) have emerged as key regulators of gene expression in bacteria. Although significant progress has been made in the past 10 years in understanding their function, the enormous number of identified non-coding RNAs has opened a new field of research of not yet fully appreciated relevance. What are their functions? How do they act? How can we exploit them? This EMBO Global Exchange Lecture course will cover different aspects of non-coding RNAs, including their genetics & genomics, mechanisms of action, identification strategies, and characterised biological functions.
The goals of the course are:
1) to provide an intensive theoretical training in one of the frontlines of scientific research in the field of molecular microbiology;
2) to contribute to the development of non-coding RNA research area in Latin America.
A group of outstanding pioneers in non-coding RNA research have committed to participate in this exciting course to share their experience with enthusiastic students and to discuss upcoming challenges in the field.
The EMBO Global Exchange Lecture Course aims to provide intensive theoretical training in the biology of bacterial non-coding RNA molecules. A group of outstanding pioneers in non-coding RNA research have agreed to participate in this exciting course: they will share their experience with enthusiastic students and discuss upcoming challenges in the field.
The format of the course will take place over one week, with nine speakers, 40 PhD students or postdocs. The course will provide an opportunity for young researchers from South-America and Europe to receive specific and strong theoretical training on bacterial sRNA biology. This will contribute to the further development of this research area locally and also will foster cooperation between South-American and European research groups in this field. In particular, we aim to boost research in bacterial non-coding RNAs in Latin America.
Selected students will receive accommodation and most meals (free of charge) during the course.
The course covers the following topics:
- Overview of gene regulation in bacteria,
- History of sRNA discoveries,
- Mechanisms and control of mRNA degradation,
- Trans-encoded base-pairing RNAs & assistant proteins,
- Search for sRNA targets,
- Molecular mimic sRNAs and cognate RNA binding proteins,
- Comparative genomics and identification of non-coding RNAs by RNAseq technology,
- Methodological aspects of RNAseq,
- RNA antitoxins & plasmid encoded sRNAs,
- Antisense non-coding RNAs,
- The bacterial equivalent of siRNAs: CRISPRs systems,
- The eukaryotic (plant) perspective of miRNA function: mechanisms & machinery,
- Potential applications of sRNA knowledge,
- Challenges in sRNA research.
Each speaker will give one plenary presentation (open to a large audience) and will later participate in round tables/demonstration sessions/journal clubs to introduce students to some important concepts and/or techniques of her or his work. All participating students will present their ongoing project in the afternoon poster sessions (beer & snacks will be available). Selected abstracts will be asked to present short oral talks. Discussion will be stimulated by selected oral presentations by participants, posters sessions, and journal clubs/workshops moderated by speakers. Finally, in order to encourage communication, a welcome dinner and a closing dinner will be organised for all participants. One afternoon will be free for sight-seeing and break-out sessions. All participants will be hosted in the same hotel to foster further collaborations.
Universidad Nacional de Quilmes,Provincia de Buenos Aires,
We look forward to welcoming you