ABOUT THE workshop

During neural development, exuberant connections are first formed and later eliminated by regressive changes in neuronal morphology, which establish the mature pattern of dendrites and axons. Such neuronal remodelling is widespread across the animal kingdom, from insects to humans, and forms an essential part of nervous system wiring.  As excessive or reduced neuronal remodelling might contribute to neurological diseases, remodelling is a Janus-faced process with physiological, as well as pathological roles - akin to programmed cell death. Understanding how neurites are remodeled during development should provide a broader insight into the process of axon destruction during disease and following injury. This EMBO Workshop will focus on the cellular and molecular mechanisms underlying neuronal remodelling across different animal models and their relation to the proper function of the nervous system.

This EMBO Workshop is cofunded by the Israeli Science Foundation, the Mizarchi Foundation and is also the 43rd Katzir centre supported conference.

In this EMBO Workshop, we will focus on important unresolved questions on the mechanisms of neuronal remodelling.

These will include:

  1. What cellular and molecular programs mediate neuronal remodelling? Are they conserved between different forms of remodelling?
  2. What are the similarities to other regressive phenomena, such as apoptosis, autophagy and injury induced degeneration? Which roles do glia or immune cells play in remodelling?
  3. What is the role of neuronal remodelling in brain plasticity, learning and memory?
  4. Are there "diseases of remodelling"? What is the role of remodelling in neuro-psychiatric disorders, such as schizophrenia or autism?

 

VENUE

 

   

Kibbutz Ein-Gedi is situated inside a magical botanical garden, on a cliff plateau, overlooking the Dead Sea – the lowest point on earth. It is a true oasis within the Judean Desert.

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