Programme

Day 1 - Sunday October 12

17:00 - 18:00

Arrival & Registration

18:00 - 18:15  

Opening Remarks

18:15 - 19:15

Keynote Lecture: G-actin as a regulator of protein function

Richard Treisman

19:30 - 22:00

Welcome cocktail

Day 2 - Monday October 13

Session I:          Chromatin dynamics, gene transcription and nuclear architecture

08:50 - 09:00

Welcome

09:00 - 09:30

New Insights into the Roles of the Nuclear Lamins in Regulating Nuclear Architecture and Function

Robert Goldman

09:30 – 10:00

Nuclear Mechanics and Genome Regulation

Shivashankar GV

10:00 - 10:30

Higher order chromatin organization by nucleoplasmic A-type lamins

Roland Foisner

10:30 - 11:00           

Mechanisms of Heterochromatin Positioning in the Nucleus

Irina Solovei

11:00 - 11:30

Coffee break

11:30 - 12:00

Tissue-specific nuclear envelope proteins contribute to differentiation by influencing gene expression through spatially organizing the genome

Eric Schirmer

12:00 -12:30

ATR mediates a mechanical response at the nuclear envelope following membrane stress

Marco Foiani

12:30-12:45

A key role for A-type lamins in T cell activation

Jose Maria Gonzalez-Granado

12:45-13:00

Matrix stiffness induces redox modification of lamin A to potentiate vascular smooth muscle cell contractile differentiation

Derek Warren

13:00 - 14:30

Lunch

14:30 - 18:00

POSTER SESSION

19:00 - 20:30

Dinner for invited speakers

Day 3 - Tuesday October 14

Session II: Nuclear envelope and genome instability

09:00 - 09:30

Synthetic lethal screen reveals a role for p53 in genome stability

Cheok Chit Fang

09:30 - 10:00

The effects of heterochromatin detachment from the nuclear periphery in C. elegans embryos

Adriana Gonzalez

10:00 - 10:30

Lamin A in the maintenance of genome stability and aging

Zhongjun Zhou

10:30 - 11:00

Molecular mechanisms contributing to genomic instability in laminopathies provide new therapeutic opportunities

Susana Gonzalo

11:00 - 11:30           

Coffee break

11:30 - 12:00

Tumor protection in a pre-mature aging disorder

Tom Misteli

12:00 -12:30

Catastrophic nuclear envelope collapse in cancer cell micronuclei

Martin Hetzer

12:30-12:45

Elevating micronuclei formation contributes to post-slippage antiproliferative action of anti-mitotic drugs

Karen Crasta

12:45-13:00

Nuclear position dictates DNA repair pathway choice

Evi Soutoglou

13:00 - 14:30

Lunch

Session III:        Nuclear organization and disease

14:30 -15:00

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

Sue Shackleton

15:00 -15:30

The consequences of Lamin A Progeric and progeroid mutations

Colin Stewart

15:30 - 16:00

Missing LINCs: from hearing loss to infertility

Brian Burke

16:00 - 16:30

Coffee break

16:30 - 17:00

The role of lamins in development and aging

Yixian Zheng

17:00–17:15

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

Delphine Larrieu

1715-17:30

A Giant KASH-less Isoform of Nesprin1 Underlies the Molecular Etiology of Autosomal Recessive Cerebellar Ataxia Type 1 (ARCA1) (S23)
Didier Hodzic

18:00 - 21:30    

Workshop Networking

Day 4 – Wednesday October 15

Session IV:       Cytoskeleton and cell plasticity

09:00 - 09:30

Epidermal stem cell-niche interactions

Fiona Watt

09:30 - 10:00

Probing the nuclear pore complex with BioID

Kyle Roux

10:00 - 10:30

How to reach the nucleus from the cell surface, early studies on stapled peptide activators of p53 dependant transcription

David Lane

10:30 - 11:00           

Coffee break  

11:00-11:15

Journey to the center of the cell

Frederic Bard

11:15-11:30

The nucleoskeleton couples cell spreading to nuclear actin polymerization

Matthias Plessner 

11:30-11:45 MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells (S29)
Mohammed Hakim Jafferali

11:45-12:00

Mechanisms of Aurora Kinases in Maintenance of Chromosome Stability and Nuclear Integrity (S30)
Sang Hyun Lee

12:00 - 12:30

SUN and KASH proteins span the nuclear envelope and coordinate with actin to move nuclei through constricted spaces

Daniel A. Starr

12:30 - 12:45

Concluding remarks

13:00

End of event and departure