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Macromolecular assemblies at the crossroads of cell stress and function

31 May – 4 June 2015 | Jerusalem, Israel

 

About the workshop

Recent work has highlighted the sub-organellar meso-scale of protein organization has gained increasing attention as an essential mediator of protein folding, function, proteostasis, transcription, translation, and RNA metobolism. In particular, stress-induced RNP granules and protein inclusions are emerging as essential elements of the quality control architecture on one hand, and causal agents of several age-associated diseases on the other hand. These nano-scale macromolecular assemblies (or Dynamic Droplets) provide a platform for rapid protein and nucleic acid transport, and for rapid response to changing conditions, but can also serve as targets for pertrubation by dysfunctional proteins. A variety of membraneless sub-organellar structures such as Inclusions, complex protein mixtures, aggregates, Stress Foci, Stress Granules, P-bodies, P-Granules, and quality control compartments (JUNQ and IPOD) have been identified and have been shown to play a central role in the changes that the cell undergoes during aging and in models of human neurodegenerative disease. In this EMBO Workshop we will explore recent developments in the field and examine models of aging and disease, and their emerging connection to nano-scale organization of the cytoplasm and RNP granules, as well as protein and RNA quality control.

This EMBO Workshop was designed to bring together leading experts on human aging-related diseases as well as animal models of aging and disease, high-resolution and single molecule live cell imaging of biological events relevant to understanding stress response, biophysical and theoretical analysis of protein organization in the cytoplasm, and cell biology of protein folding quality control. 

Topics that will be covered:

  • RNP granules in RNA quality control and dynamics
  • Meso-scale organization of protein mixtures and phase transitions in the cytoplasm
  • Aggregation, stress, and brain diseases
  • RNA and Neurodegeneration
  • Cellular architecture of protein quality control and aggregation
  • Aging, replicative rejuvenation, and asymmetric inheritance
  • Inclusions in cellular regulation and disease
  • Protein degratation in proteostasis and quality control

 

Registration and registration deadline

15 April 2015

Apply now!

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poster

Download poster

 

 

 
Speakers
 

Programme

 

 

Registration

Early registration deadline

15 February 2015

Late registration deadline

15 April 2015

Abstract submission deadline

15 April 2015

 

 

FULL REGISTRATION  

Early - Until 15.02.2015

EUR470

Students

EUR400

Regular - 16.02.2015-15.04.2015

EUR650

Onsite

EUR700

Industry

EUR900

 

Online application

Apply now!

 

 

 

Daily Registration: Early - Until 15.02.2015 Regular 16.02.2015-15.04.2015
Sunday, May 31
Daily registration fee including participation in scientific sessions, coffee/refreshment and lunch

Option to add: opening reception including dinner and wine
EUR 62 (NIS 300)




EUR 55 (NIS 270)
EUR 70 (NIS 340)




EUR 55 (NIS 270)
Monday, June 1
Daily registration fee including participation in scientific sessions, coffee/refreshment and lunch

Option to add: Dinner and entertainment with beer and wine
EUR 62 (NIS 300)




EUR 50 (NIS 230)
EUR 70 (NIS 340)




EUR 55 (NIS 270)
Tuesday, June 2
Daily registration fee including participation in scientific sessions, coffee/refreshment, lunch and a hike to Sataf (near Jerusalem)

Option to add: Dinner and entertainment with beer and wine
EUR 65 (NIS 320)





EUR 50 (NIS 230)
EUR 70 (NIS 340)





EUR 55 (NIS 270)
Wednesday, June 3
Daily registration fee including participation in scientific sessions, coffee/refreshment, lunch, Poster session and excursion to the city of David

Option to add: Dinner and entertainment with beer and wine
EUR 65 (NIS 320)






EUR 50 (NIS 230)
EUR 70 (NIS 340)






EUR 55 (NIS 270)
Thursday, June 4
Daily registration fee including participation in scientific sessions, coffee/refreshment and lunch

Option to add: Dinner and Farewell party 
EUR 62 (NIS 300)




EUR 55 (NIS 270)
EUR 70 (NIS 340)




EUR 55 (NIS 270)

 

 

 

Registration Fee includes:

  • accommodation
  • Lunch

 

selection Ctiteria

Participants will be selected on a first come first served basis.

Payment

Please follow this link for payment: https://www.as.huji.ac.il/new/2/2.php

 

 

 

 

Contact

Sara Burstin

Phone: +972 2 6585815

Email: sarabu@savion.huji.ac.il

 

 

 

Location

The Israel Institute for Advanced Studies (IIAS) of Jerusalem is a national institution devoted to academic research. Located at The Hebrew University of Jerusalem, on the Edmond J. Safra campus at Givat Ram, the IIAS is a self-governing body, both in its administrative function as well as its academic pursuit.

The primary function of the Institute is to encourage and support collaborative research. Along with collaborative Research Groups, the Institute annually hosts five Advanced Schools as well as many conferences.

The Institute was founded in 1975 to provide a nurturing and stimulating academic environment, championing outstanding scholarly research in a wide range of disciplines. It brings together scholars from around the world to engage in collaborative research projects for periods of five and ten months. International collaboration is also fostered through our many conferences and our Advanced Schools.

The Institute is similar in concept to several existing Institutes of Advanced Study, yet also unique in its sponsoring unrestricted academic research and hosting collaborative teams throughout the more than thirty-five years since its establishment.

One day of the conference will be held at the Weizmann Institute which is located in the town of Rehovot, 22 kilometers south of Tel Aviv and 42 kilometers west of Jerusalem. The organizers will arrange buses for the participants.

venue map

Hotel Jerusalem Gardens

Hotel Prima Park

Transport

Getting to the hotel:

From the airport you can take a taxi which will take you directly to the hotel in Jerusalem and that will cost around 280 ILS depending on the amount of passengers and luggage. There is another type of taxi called "Nesher", which are small buses for up to 10 passengers. They are cheaper but the driver will wait until he has 10 passengers before he'll start the journey to Jerusalem.

Since you are most likely to arrive on Saturday, we remind you that it's the Jewish holy day of rest which means that there will be no public transportation and most shops will be closed.

 

Accommodation

Participants will be staying at 2 hotels which are located right next to each other. Speakers will be staying at the "Jerusalem Gardens" hotel and other participants will be staying at the "Prima Park" hotel.
2 Students can decide to share a room in which case they each have to pay 300 EU.
Both hotels (Prima Park and Ganei Jerusalem) are located between the city entrance and the Israeli Knesset, and near many cardinal Jerusalem sites such as the government offices, the Israel Meuseum, the Science Meuseum, the Supreme Court, Sacher Park and more. The hotel's proximity to the central bus station and to the light rail way will also allow you easy and fast access to any location in Jerusalem.

 

Sponsors