ABOUT THE LECTURE COURSE
Structural methods applicable to solutions offer a unique opportunity to carry out structural and functional studies on biological macromolecules under close to native conditions. Fully exploiting this opportunity allows one to extract the maximum amount of biologically meaningful information and to relate the structural results to the function of the system. We aim for a comprehensive coverage of the major structural and biophysical techniques for characterization of high and low resolution structure and structural transitions, macromolecular complex formation, protein folding, stability, interactions and enzymatic mechanisms.
Following methods will be covered:
- small-angle X-ray and neutron scattering (SAXS/SANS);
- nuclear magnetic resonance (NMR);
- static and dynamic light scattering (SLS/DLS);
- analytical ultracentrifugation (AUC);
- differential and isothermal calorimetry (DSC/ITC);
- spectroscopic approaches;
- macromolecular crystallography (MX) and electron microscopy (EM).
Institute of Biological Chemistry
We look forward to welcoming you