RNA transport and local translation are critical for the development and function of polarized cells in diverse organisms, contributing to the patterning of embryos, development of asymmetry, and the function of neurons. A growing awareness that RNA-based molecules and mechanisms are often conserved has stimulated interactions and collaborations among scientists from diverse fields. Furthermore, the advent of new techniques to study RNA-mediated regulation of gene expression, together with new roles for small noncoding RNAs has generated widespread interest and excitement within the community. This second EMBO conference series, which started in 1993, continues with the long-standing tradition of being the most important meeting in the field bringing together the key labs in this area. This EMBO conference promotes open communication and fosters international collaborations that span systems and disciplines. From studies in multiple cell types and systems, an understanding of the genetic, biochemical, structural and cell biological bases of RNA localization and local translation are beginning to emerge. These studies have important implications for human health, as mutations in genes encoding RNA-binding proteins underlie many diseases. The proposed meeting will be timely and of broad interest to a growing number of scientists interested in RNA trafficking, translational control and RNA-mediated regulation. Plenary lectures will be given by Dave Bartel, Anne Ephrussi, and Steve McKnight.
Topics to be discussed include:
- the transport and localization of RNA in polarized cells and neurons
- local protein synthesis in developmental and synaptic plasticity
- regulatory roles small and long ncRNAs
- structural basis of RNA and protein interactions