About the workshop
The Golgi apparatus has long been studied as a key sorting station that is required for the appropriate targeting of nearly a third of the proteins encoded in the mammalian genome. An equally important function of this organelle is modification of cargo by glycosylation. Glycosylation mediates intercellular interactions and signalling, and is thus a key regulator of multicellularity.
The cargo trafficking mechanisms and the glycosylation activities of the Golgi have been studied extensively but separately, leading to the development of two rather distinct research fields, which have interacted poorly over the years. This EMBO Workshop will emphasize a "cultural" exchange between researchers working in these two complementary fields to accelerate progress towards answering such basic questions as:
- What is the role of membrane trafficking in the organization of the glycosylation machinery in the Golgi?
- How does this organization influence the functions of glycosyltransferases?
- How are the trafficking and glycosylation functions of the Golgi coordinated?
- At a systems level, what is the relationship between the distribution of the glycosylation machinery in different tissues, and the cargoes modified?
- How does glycosylation regulate cellular and organismal homeostasis?