The modularity of signaling proteins and networks (w16-30)
Seefeld in Tirol, Austria, 20 – 25 September 2016
Tuesday, 20 September 2016
18:30 - 20:00
Dinner
20:00 - 21:45
Session 1
Oral presentations
Title
Disassembling and reassembling signalling networks
20:00 - 20:45
Session 1-T01-K-01
A Periodic Table of Protein Complexes
Sarah Teichmann
Wellcome Trust Sanger Institute, Cambridge, United Kingdom
20:45 - 21:30
Session 1-T01-K-02
Programming and Perturbing Cell Signaling Networks
Wendell Lim
Howard Hughes Medical Institute / University of California San Francisco, San Francisco, United States
Wednesday, 21 September 2016
09:00 - 10:30
Session 2
Oral presentations
Title
Ubiquitin and related modifications
09:00 - 09:30
Session 2-T01-I-01
Molecular mechanism of multi-domain E3 ligases that regulate immune signalling
Katrin Rittinger, Marios Koliopoulos, Diego Esposito
The Francis Crick Institute, London, United Kingdom
09:30 - 10:00
Session 2-T01-I-02
Signalling via polyubiquitin chains in replicative DNA damage bypass
Sabrina Batke1, Tomio Takahashi2, Hans-Peter Wollscheid1, Helle Ulrich1
1Institute of Molecular Biology (IMB), Mainz, Germany, 2Structural Biology Laboratory, University of Tokyo, Tokyo, Japan
10:00 - 10:30
Session 2-T01-I-03
Regulation of Parkin E3 ligase activity.
Helen Walden, et al.
University of Dundee MRC Phosphorylation adn ubiquitylation unit, Dundee, United Kingdom
10:30 - 11:00
Coffee break
11:00 - 12:30
Session 3
Oral presentations
Title
Ubiquitin and related modifications
11:00 - 11:30
Session 2b-T01-I-01
Chromatin Replication: A histone reader based mechanism to identify post-replicative chromatin
Anja Groth
Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
11:30 - 11:45
Session 2b-T01-O-02
Tandem SIM module reveals mechanics of SUMO polymer assembly
Chaugule Viduth
MRC Protein Phosphorylation and Ubiquitylation, Dundee, United Kingdom, Max Planck Institute of Immunobiology and Epigenetics,, Freiburg, Germany
11:45 - 12:00
Session 2b-T01-O-03
Multivalent histone and DNA engagement by the triple reader module of ZMYND8 directs the recruitment of a transcriptional network to genes to regulate gene expression
Pavel Savitsky1, Tobias Krojer1, Takao Fujisawa2, Jean-Philippe Lambert3, Sarah Picaud1, Chen-Yi Wang2, Erin Shanle4, Krzysztof Krajewski4, Hans Friedrichsen2, Alexander Kanapin5, Panagis Filippakopoulos1, 2, et al.
1Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK, Oxford, United Kingdom, 2Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building Roosevelt Drive, Oxford, OX3 7DQ, UK., Oxford, United Kingdom, 3Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, 600 University Ave, Toronto, ON, M5G 1X5, Canada., Toronto, Canada, 4Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA, Chapel Hill, United States, 5Department of Oncology, Gray Laboratories, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK, Oxford, United Kingdom, 6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Chapel Hill, United States, 7Structural Genomics Consortium, MaRS Centre, South Tower 101 College St., Suite 700 Toronto, ON, M5G 1L7 Canada., Toronto, Canada, 8Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada, Toronto, Canada, 9Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Toronto, Canada
12:00 - 12:30
Session 2b-T01-I-04
Allosteric activation of an oncogenic chromatin remodeler by poly-ADP-ribose
Andreas Ladurner1, 4, 5, Hari Singh1, Aurelio Nardozza1, Ingvar Möller2, Dmitri Filippov3, Kasper Rand2
1Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Munich, Germany, 2Protein Analysis Lab, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark, 3Gorlaeus Laboratories, Leiden Institute of Chemistry, Leiden, Netherlands, 4Center for Integrated Protein Science Munich, Munich, Germany, 5Munich Cluster for Systems Neurology, Munich, Germany
12:30 - 14:00
Lunch
14:00 - 18:30
Open
18:30 - 20:00
Dinner
20:00 - 22:00
Session 4
Oral presentations
Title
Signalling models and algorithms
20:00 - 20:30
Session 3-T01-I-01
Condition dependent action of signaling pathways exemplified for yeast – Integration of mathematical modeling and dedicated experiments on different scales
Edda Klipp
Humboldt-Universität zu Berlin, Theoretical Biophysics, Berlin, Germany
20:30 - 21:00
Session 3-T01-I-02
Improving Cancer Treatments through Executable Modelling of Cell Signalling
Jasmin Fisher
Department of Chemistry, University of Cambridge & Microsoft Research, Cambridge, United Kingdom
21:00 - 21:15
Session 3-T01-O-03
Integrative approach identifies cell cycle gene regulatory networks
Martin Fischer, et al.
Molecular Oncology, Medical School, University of Leipzig, Leipzig, Germany, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States, Department of Medicine, Harvard Medical School, Boston, United States
21:15 - 21:30
Session 3-T01-O-04
The genetic interaction landscape of HIV infection in human cells
David Gordon, Ariane Watson, Assen Roguev, Raj Bhatnagar, David Crosby, Nevan Krogan
University of California San Francisco, San Francisco, United States
21:30 - 22:00
Session 3-T01-I-05
Identifying Functional Genetic Variants in Cancer using Protein Domains and Binding Sites
Gary Bader
University of Toronto, Toronto, Canada
Thursday, 22 September 2016
09:00 - 10:30
Session 5
Oral presentations
Title
Signalling networks and evolution
09:00 - 09:30
Session 4-T01-I-01
Lipid-protein interactions
Anne-Claude Gavin
European Molecular Biology Laboratory, Heidelberg, Germany
09:30 - 10:00
Session 4-T01-I-02
Multilevel modeling of muscle regeneration.
Gianni Cesareni
University of Rome Tor Vergata, Rome, Italy
10:00 - 10:30
Session 4-T01-I-03
Sixty thousand tumors: learning the signaling logic of cancer from massive mutation profiling
Gerard Manning
Genentech, South San Francisco, United States
10:30 - 11:00
Coffee break
11:00 - 12:30
Session 6
Oral presentations
Title
Signalling networks and evolution
11:00 - 11:30
Session 4b-T01-I-01
Decoding of Network Attacking Mutations Rewiring Cancer
Rune Linding, et al.
UCPH, Copenhagen, Denmark
11:30 - 11:45
Session 4b-T01-O-02
Analysis of the phosphotyrosine proteome and identification of target proteins in childhood neuroblastoma by SH2 profiling
Tu-Lan Vu-Han, Helwe Gerull, Sophia Buhs, Martin Horstmann, Peter Nollau
Research Institute Children’s Cancer Center and Dept. of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
11:45 - 12:00
Session 4b-T01-O-03
DUSP3 Signals for Proliferation and Genomic Stability in Human Cells
Fabio Forti, et al.
Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil
12:00 - 12:30
Session 4b-T01-I-04
Evolution and function of protein phosphorylation networks
Pedro Beltrao
EMBL-EBI, Hinxton, Cambridge, United Kingdom
12:30 - 14:00
Lunch
14:00 - 18:30
Open
18:30 - 20:00
Dinner
20:00 - 21:30
Session 7
Oral presentations
Title
Linear motifs and evolution
20:00 - 20:30
Session 5-T01-I-01
Functional versatility and regulation of proteins with intrinsically disordered regions
Madan Babu Mohan
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
20:30 - 21:00
Session 5-T01-I-02
Discovery and Characterisation of Novel Functional Modules in Intrinsically Disordered Regions
Norman Davey, et al.
Conway Institute of Biomolecular & Biomedical Research, University College Dublin,, Dublin, Ireland
21:00 - 21:30
Session 5-T01-I-03
Why is it so difficult to define patterns representing linear motifs?
Toby Gibson
EMBL Heidelberg Meyerhofstraße 1, 69117 Heidelberg, Germany
21:30 - 23:00
Session 8
Poster session
21:30 - 23:00
Poster Session 1-T02-P-01
A chemical genetics- and systems biology-oriented approach to the targeted degradation of nuclear and mitochondrial genomes in cancer cells
Stephan Bartsch, Sebastian Janowski, and Ralf Hofestädt
Center for Biotechnology and Medical Informatics Department, Bielefeld University, Universitätsstrasse 25, D-33501 Bielefeld, Germany
21:30 - 23:00
Poster Session 1-T02-P-02
Perturbation of muscle multipotent stem cells differentiation trajectories to counteract muscle myopathies
Andrea Cerquone Perpetuini, Alberto Calderone, Francesca Langone, Elisa Micarelli, Theodora Pavlidou, Stefano Pirrò, Alessio Reggio, Filomena Spada, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni
Department of Biology, University of Rome Tor Vergata, Rome, Italy
21:30 - 23:00
Poster Session 1-T02-P-03
The Executable Pathway to c-myc
Matthew Clarke1, Peter Kreuzaler1, Trevor Littlewood1, Gerard Evan1, Jasmin Fisher1, 2
1Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, 2Microsoft Research, Cambridge, United Kingdom
21:30 - 23:00
Poster Session 1-T02-P-04
Modelling concerted cell velocity in wound healing assays
Mathias Engel1, 2, Jesper Ferkinghoff-Borg1, Xavier Robin1, Gaye Sağınç1, James Longden1, Rune Linding1
1Linding Lab, UCPH, BRIC, Copenhagen, Denmark, 2Niels Bohr Institute, UCPH, Copenhagen, Denmark
21:30 - 23:00
Poster Session 1-T02-P-05
Uncovering melanoma's adaptive resistance to RAF inhibitors using drug pulse modulation
Luca Gerosa1, 2, Kartik Subramanian1, 2, Mohammad Fallahi-Sichani1, 2, Peter Sorger1, 2
1Department of Systems Biology, Harvard Medical School, Boston 02115, United States, 2Laboratory of Systems Pharmacology, Harvard Medical School, Boston 02115, United States
21:30 - 23:00
Poster Session 1-T02-P-06
Analysis of HLA protein sequences and binding specificity predicts co-operative effects in HLA-peptide interactions and reveals uncoupling between HLA polymorphism and inter-species amino acid co-evolution.
David Gfeller
Ludwig Center for Cancer Research University of Lausanne, Lausanne, Switzerland
21:30 - 23:00
Poster Session 1-T02-P-07
Design and characterization of RNA origami nanostructures for protein scaffolding
Guido Grossi1, Steffen Sparvath1, Cody Geary1, 2, Ebbe Andersen1
1Aarhus University, Aarhus, Denmark, 2California Institute of Technology, Pasadena, United States
21:30 - 23:00
Poster Session 1-T02-P-08
Targeting SUMOylation processes with intracellular affinity reagents
Suchitra Guntur, Svenja Wiechmann, et al.
Institute of Biochemistry II / Goethe-University Frankfurt, Frankfurt, Germany
21:30 - 23:00
Poster Session 1-T02-P-09
Visualizing Signaling Associated Protein Complexes as Molecular Diagnostics
Eric Haura
Moffitt Cancer Center, Tampa, United States
21:30 - 23:00
Poster Session 1-T02-P-10
Modulating the Interaction of Tumor and NK Cells with Small Molecules
Nikolaus Krall, Gregory Vladimer, Berend Snijder, Giulio Superti-Furga
CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
21:30 - 23:00
Poster Session 1-T02-P-11
Towards highly specific monobody antagonists to the Src and Cbl family SH2 domains
Tim Kükenshöner1, Nadine Schmit1, Akiko Koide2, 3, Fern Sha2, Shohei Koide2, 3, Oliver Hantschel1
1Swiss Institute for Experimental Cancer Research (ISREC), Ecole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Biochemistry and Molecular Biology, The University of Chicago,, Chicago, United States, 3Perlmutter Cancer Center & Department of Biochemistry and Molecular Pharmacology NYU Langone Medical Center, New York City, United States
21:30 - 23:00
Poster Session 1-T02-P-12
ELM - the Eukaryotic Linear Motif resource
Manjeet Kumar, Holger Dinkel, Vladislava Milchevskaya, Hugo Sanchez, Benjamin Lang, Toby Gibson
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
21:30 - 23:00
Poster Session 1-T02-P-13
Signalosome-oriented SH2 Profiling of B-cell Malignancies
Kazuya Machida, Adam Lafontaine, Bruce Mayer
Department of Genetics and Genome Sciences, Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, University of Connecticut School of Medicine, Farmington, CT, United States, Farmington, United States
21:30 - 23:00
Poster Session 1-T02-P-14
SH2 domains enhance phosphorylation in vivo by protecting their binding sites from dephosphorylation
Joshua Jadwin1, Timothy Curran2, Forest White2, Bruce Mayer1
1University of Connecticut School of Medicine, Farmington, United States, 2Massachusetts Institute of Technology, Cambridge, United States
21:30 - 23:00
Poster Session 1-T02-P-15
STAT5BN642H is a driver mutation for leukaemia
Ha T. T. Pham1, 2, Barbara Maurer1, 2, Michaela Prchal-Murphy3, Eva Grundschober3, Harini Nivarthi4, Tahereh Javaheri1, 2, Jan Pencik1, Zahra Kazemi2, 5, Florian Grebien1, Lukas Kenner1, 2, 7, Peter Valent2, 8, et al.
1Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria, 2Medical University Vienna, Vienna, Austria, 3Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria, 4CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 5Center of Physiology and Pharmacology, Vienna, Austria, 6Institute of Animal Breeding and Genetics & Biomodels Austria, University of Veterinary Medicine Vienna, Vienna, Austria, 7Clinical Institute of Pathology, Vienna, Austria and Unit of Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, Vienna, Austria, 8Department of Medicine I, Division of Hematology and Ludwig-Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria
21:30 - 23:00
Poster Session 1-T02-P-16
SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes
Shankha Satpathy1, Sebastian Wagner1, 2, Petra Beli1, 3, Chunaram Choudhary1
1The Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark, 2Goethe University School of Medicine, Frankfurt, Germany, 3Institute of Molecular Biology, Mainz, Germany
21:30 - 23:00
Poster Session 1-T02-P-17
Clustered arginine methylation in control of human RNA processing efficacy
Jonathan Woodsmith1, Victoria Casado2, Ulrich Stelzl1, et al.
1University Of Graz, Berlin, Germany, 2Pennsylvania State University, Philidelphia, United States
21:30 - 23:00
Poster Session 1-T02-P-18
FERM-mediated interactions of Merlin and their potential implications in signaling pathways
vikash Kumar Yadav1, Gustav Sundell1, Eduard Resch2, Ylva Ivarsson1
1Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden, 2Fraunhofer IME, Frankfurt, Sweden
Friday, 23 September 2016
09:00 - 10:30
Session 9
Oral presentations
Title
Signalling networks in health and disease
09:00 - 09:30
Session 6-T01-I-01
Functional interactome of phosphatases in mitosis
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
09:30 - 09:45
Session 6-T01-O-02
Pooled screening for antiproliferative inhibitors of protein-protein interactions
Philip Kim
University of Toronto, Toronto, Canada
09:45 - 10:00
Session 6-T01-O-03
Interaction profiling through proteomic peptide phage display
Norman Davey1, Moon-Hyeong Seo2, Vikash Yadav3, Satra Nim2, Jouhyun Jeon2, Cecilia Blikstad3, Izabella Krystkowiak1, Debbie Dong2, Natalia Markova4, Philip M Kim1, Ylva Ivarsson3
1Conway Institute of Biomolecular and Biomedical Sciences, University College, Dublin, Ireland, 2Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, 3Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden, 4Malvern, Solna, Sweden
10:00 - 10:30
Session 6-T01-I-04
Opposing effects of dystroglycan WW motif phosphorylation in muscular dystrophy and hearing.
Steve Winder
University of Sheffield, Sheffield, United Kingdom
10:30 - 11:00
Coffee break
11:00 - 12:30
Session 10
Oral presentations
Title
Signalling networks in health and disease
11:00 - 11:15
Session 6b-T01-O-01
Integrative analysis of multiple integrin adhesion complex proteomes defines a core consensus adhesome and reveals how it might work
Edward Horton1, 2, Adam Byron1, Ben Stutchbury1, Christoph Ballestrem1, Jonathan Humphries1, Janine Erler2, Martin Humphries1
1Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom, 2Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
11:15 - 11:30
Session 6b-T01-O-02
synergy of protein interaction peptides in the integrin adhesome
Kevin O'Brien1, Kalyan Golla2, Tilen Kranjc1, Darragh O'Donovan1, Seamus Allen1, Patricia Maguire1, Jeremy Simpson1, David O'Connell1, Niamh Moran2, Denis Shields1
1University College Dublin, Ireland, 2Royal College of Surgeons in Ireland, Dublin, Ireland
11:30 - 11:45
Session 6b-T01-O-03
Linear motif modules joined by a flexible linker determine displacement ability of an intrinsically disordered viral oncoprotein
Nicolás Foutel1, Juliana Glavina2, Ignacio Sánchez2, Lucia Chemes1
1Protein Structure Function and Engineering Laboratory, Lelor Institute, Buenos Aires, Argentina, 2Protein Physiology Laboratory. Biological Chemistry Department, Faculty of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina
11:45 - 12:00
Session 6b-T01-O-04
Predicting Motif Mimicry in Viruses
Sobia Idrees, Åsa Pérez-Bercoff, Richard Edwards
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
12:00 - 12:30
Session 6b-T01-I-05
Binding affinity and selectivity of SH3 domain interactions by cellular and viral ligands
Kalle Saksela
Department of Virology, University of Helsinki, POB 21 (Haartmaninkatu 3), 00014, Helsinki, Finland
12:30 - 14:00
Lunch
14:00 - 18:30
Open
18:30 - 20:00
Dinner
20:00 - 21:30
Session 11
Oral presentations
Title
Cancer networks and pharmacological approaches
20:00 - 20:30
Session 7-T01-I-01
Integration of functional modules of co-regulated membrane transporters across the metabolic and signaling space
Giulio Superti-Furga1, 2, Adrian Cesar-Razquin1, Manuele Rebsamen1, Konstantinos Papakostas1, Katrin Hörmann1, Astrid Fauster1, Anna Moskovskich1, Justyna Konecka1, Berend Snijder1, Enrico Girardi1
1CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 2Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
20:30 - 20:45
Session 7-T01-O-02
Role of WW domain-containing proteins in mechanotransduction, Golabi-Ito-Hall syndrome and Ebola virus egress
Marius Sudol
National University of Singapore, Singapore, Singapore, Mechanobiology Institute, Singapore, Singapore, IMCB A*STAR, Singapore, Singapore
20:45 - 21:00
Session 7-T01-O-03
Interactors of cancer-related proteins have key influence on carcinogenesis – a novel observation found in four cancer types increasing the drug target space for anti-cancer therapies
Tamas Korcsmaros1, 2, 3, Dezso Modos1, 2, 3, 4, 5, David Fazekas2, 4, Krishna Bulusu5, Johanne Brooks4, 6, 7, Istvan Marczell8, Peter Szabo8, 9, Tibor Vellai2, Peter Csermely10, Katalin Lenti4, Andreas Bender5
1Gut Health and Food Safety Programme; Institute of Food Research, Norwich, United Kingdom, 2Department of Genetics, Eötvös Loránd University, Budapest, Hungary, 3TGAC, Norwich, United Kingdom, 4Department of Morphology and Physiology, Faculty of Health Science, Semmelweis University, Budapest, Hungary, 5Centre for Molecular Informatics, University of Cambridge, Cambridge, United Kingdom, 6Faculty of Medicine and Health, University of East Anglia, Norwich, United Kingdom, 7Department of Gastroenterology, Norfolk and Norwich University Hospitals, Norwich, United Kingdom, 82nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, 9Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, United States, 10Department of Medical Chemistry, Semmelweis University, Norwich, United Kingdom
21:00 - 21:30
Session 7-T01-I-04
Molecular basis for assembly and action of ‘nanocomputers’ within human cells
Stephan Feller, et al.
Institute of Molecular Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany
21:30 - 23:00
Session 12
Poster session
21:30 - 23:00
Poster Session 2-T02-P-01
Mechanistic insights into the interactions of silica modified titanium dioxide nanoparticles with human serum albumin: A multispectroscopic approach
Mohd Shamoon Asmat, Qayyum Husain
Department of Biochemistry, Faculty of Life Sciences Aligarh Muslim University, Aligarh, India
21:30 - 23:00
Poster Session 2-T02-P-02
ARQ087 inhibits fibroblast growth factor receptor (FGFR) signaling and rescues aberrant cell proliferation and differentiation in experimental models to craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3
Lukas Balek1, 2, Marcela Buchtova1, 3, Pavel Krejci2, 4, et al.
1Institute of Experimental Biology, Faculty of Sciences, Masaryk University, Brno, Czech Republic, 2Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 3Institute of Animal Physiology and Genetics ASCR, Brno, Czech Republic, 4International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
21:30 - 23:00
Poster Session 2-T02-P-03
Why fat does not accumulate in the muscle of a healthy vertebrate? A systems biology approach
Milica Marinkovic, Andrea Cerquone Perpetuini, Marco Rosina, Alessio Reggio, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni
University of Rome Tor Vergata, Rome, Italy
21:30 - 23:00
Poster Session 2-T02-P-04
Substrate Recognition of BAP1: Understanding its Enzymatic Function
Pranita Hanpude, et al.
Regional Centre for Biotechnology, Faridabad, India, Manipal University, Udupi, India
21:30 - 23:00
Poster Session 2-T02-P-05
Cancer high-resolution domain-based protein interaction networks with integrated mutation impacts
Mohamed Helmy1, Omar Wagih2, Gary Bader1
1Donnelly Centre, University of Toronto, Toronto, Canada, 2The European Bioinformatics Institute, Cambridge University, Cambridge, United Kingdom
21:30 - 23:00
Poster Session 2-T02-P-06
Predicting physiologically relevant SH3 domain mediated protein-protein interactions in human
Shobhit Jain1, 2, Gary Bader1, 2
1Department of Computer Science, University of Toronto, Toronto, Canada, 2The Donnelly Centre, University of Toronto, Toronto, Canada
21:30 - 23:00
Poster Session 2-T02-P-07
An integrated approach - using sequence, structure and fluctuations - identifies specific functional and regulatory sites in protein kinases
Raju Kalaivani1, Alexandre G de Brevern2, Narayanaswamy Srinivasan1
1Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 2INSERM, U 1134, DSIMB, Paris, France
21:30 - 23:00
Poster Session 2-T02-P-08
SLiMSearch - proteome-wide discovery and annotation of functional modules in intrinsically disordered regions
Izabella Krystkowiak, Norman Davey
UCD School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
21:30 - 23:00
Poster Session 2-T02-P-09
Eukaryotic linear motifs in alternative protein isoforms
Benjamin Lang, Holger Dinkel, Toby Gibson
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
21:30 - 23:00
Poster Session 2-T02-P-10
Dynamically coupled residues within the SH2 domain of FYN are key to unlock its activity
Radu Huculeci1, 2, Elisa Cilia3, 4, Agatha Lyczek5, Lieven Buts1, 2, Markus Seeliger5, Nico van Nuland1, 2, Tom Lenaerts3, 4, 7
1Structural Biology Brussels, Vrije Universiteit Brussel,, Brussels, Belgium, 2Structural Biology Research Center, VIB, Brussels, Belgium, 3Machine Learning Group, Université Libre de Bruxelles, Brussels, Belgium, 4Interuniversity Institute for Bioinformatics in Brussels, Brussels, Belgium, 5Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, United States, 6Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands, 7AIlab, Vrije Universiteit Brussel, Brussel;, Belgium
21:30 - 23:00
Poster Session 2-T02-P-11
High-throughput determination of domain-ligand affinities by automated holdup assay allows quantification of linear motif specificities
Renaud Vincentelli3, Katja Luck4, Lionel Chiron2, Juline Poirson5, Sebastian Charbonnier1, Yves Nominé1, Gilles Travé1
1Institute of Genetics and Molecular and Cellular Biology (IGBMC) Centre for Integrative Biology Equipe labelisée Ligue Contre le Cancer INSERM, U596, CNRS, UMR7104, Université de Strasbourg, Illkirch-Strasbourg, France, 2CASC4DE, Le Lodge, 20, Avenue du Neuhof, Strasbourg, France, 3UMR 7257, CNRS, Aix-Marseille University, Architecture et Fonction des Macromole?cules Biologiques (AFMB), Marseille, France, 4Center for Cancer Systems Biology (CCSB), Harvard Medical School, and Department of Cancer Biology, Dana-Farber Cancer Institute,, Boston, Massachusetts, United States, 5UMR 7242, CNRS–Universite de Strasbourg, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
21:30 - 23:00
Poster Session 2-T02-P-12
SIGNOR: a new signaling resource
Livia Perfetto, et al.
university of Rome, Rome, Italy
21:30 - 23:00
Poster Session 2-T02-P-13
Glucose-regulated and drug perturbed beta-cell phosphoproteome reveals molecular mechanisms controlling insulin secretion
Francesca Sacco, Matthias Mann, et al.
Max Plank Institute for Biochemistry, Martinsried (close to Munich), Germany
21:30 - 23:00
Poster Session 2-T02-P-14
Bacterial Mimicry of Eukaryotic Linear Motifs
Hugo C. Samano Sanchez, Holger Dinkel, Manjeet Kumar, Benjamin Lang, Toby Gibson
European Molecular Biology Laboratory, Heidelberg, Germany
21:30 - 23:00
Poster Session 2-T02-P-15
Solution structure of CUBO, a novel domain that preferentially binds the ubiquitin-like protein NEDD8.
Elena Santonico1, Ridvan Nepravishta1, Eleonora Valentini2, Anna Mattioni1, Walter Mandaliti1, Luisa Castagnoli1, Simona Polo2, Maurizio Paci1, Gianni Cesareni1
1University of Tor Vergata, Rome, Italy, 2IFOM-IEO Campus, Rome, Italy
21:30 - 23:00
Poster Session 2-T02-P-16
Structural basis of recognition of cellular target proteins by Human Papillomavirus E6 oncoproteins
Gilles Travé, Alberto Podjarny, Alexandra Cousido-siah, Anna Bonhoure, Irina Suarez
Institute of Genetics and Molecular and Cell Biology, Illkirch, France
21:30 - 23:00
Poster Session 2-T02-P-17
Identification of phosphorylation switches through phosphomimetic proteomic peptide phage display
Gustav Sundell1, Roland Arnold2, Ylva Ivarsson1
1Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden, 2Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
21:30 - 23:00
Poster Session 2-T02-P-18
Untangling the tyrosine kinase receptor ErbB4 isoform selectivity of STAT5 signaling
Katri Vaparanta1, 2, Anne Jokilammi1, Klaus Elenius1
1Medicity Research Laboratory and department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland, 2Turku Doctoral Programme of Molecular Medicine (TuDMM), University of Turku, Turku, Finland
21:30 - 23:00
Poster Session 2-T02-P-19
Generation and characterization of phosphospecific affinity reagents based on the Forkhead-associated domain
Leon Venegas, Brian Kay
University of Illinois at Chicago, Chicago, United States
Saturday, 24 September 2016
09:00 - 10:30
Session 13
Oral presentations
Title
Molecular network engineering
09:00 - 09:30
Session 8-T01-I-01
Modular RNA origami scaffolds for the spatial organization of proteins
Cody Geary1, 2, Ebbe Andersen1
1Interdisciplinary Nanoscience Center and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark, 2California Institute of Technology, Pasadena, United States
09:30 - 09:45
Session 8-T01-O-02
Using the principles of domain modularity to enhance phosphoprotein production
Kristen Naegle, et al.
Washington University in St Louis, St. Louis, United States
09:45 - 10:00
Session 8-T01-O-03
Integrating affinity maturation into the phage-display pipeline
Kevin Gorman1, Renhua Huang1, 2, Brian Kay1
1University of Illinois at Chicago, Chicago, United States, 2Meso Scale Discovery, Rockville, United States
10:00 - 10:30
Session 8-T01-I-04
Mechanisms of T cell receptor signaling by phase transition
Xiaolei Su1, 2, Jonathon Ditlev1, 3, Enfu Hui1, 2, Michael Rosen1, 3, Ronald Vale1, 2
1The HHMI Summer Institute, Marine Biological Laboratory, Woods Hole, United States, 2Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States, 3Department of Biophysics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States
10:30 - 11:00
Coffee break
11:00 - 12:30
Session 14
Oral presentations
Title
Molecular network engineering
11:00 - 11:30
Session 8b-T01-I-01
Functional analysis of mutational perturbations in protein-protein interaction networks
Tanja Kortemme
University of California, San Francisco, San Francisco, United States
11:30 - 11:45
Session 8b-T01-O-02
kinetically controlled effector recruitment in signaling by receptor tyrosine kinases
Dongmyung Oh, Joshua Jadwin, Mari Ogiue-Ikeda, Kazuya Machida, Bruce Mayer, Ji Yu
UConn Health Center, Farmington, United States
11:45 - 12:00
Session 8b-T01-O-03
Bi-directional open-close regulation of tight junction using PDZ domain inhibitors.
Takeshi TENNO, Natsuko GODA, Hidekazu HIROAKI
Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya City, Japan
12:00 - 12:15
Session 8b-T01-O-04
Cellular modelling of Type IA PI3K dynamics in health and disease
Ralitsa Radostinova Madsen1, Michael Harris2, 3, Rachel Knox1, John James2, 3, Robert Semple1
1University of Cambridge Metabolic Research Laboratories, MRC-Wellcome Trust Institute of Metabolic Science, Cambridge, United Kingdom, 2University of Cambridge MRC-Laboratory of Molecular Biology, Cambridge, United Kingdom, 3University of Cambridge Department of Medicine, Cambridge, United Kingdom
12:15 - 12:30
Session 8b-T01-O-05
Peptide binding specificity landscape of human SH3 domains
Joan Teyra1, Haiming Huang1, Shobhit Jain1, Jinrong Min2, Yufeng Tong2, Gary Bader1, Sachdev Sidhu1
1The Donnelly Centre, University of Toronto, Toronto, Canada, 2Structural Genomics Consortium, University of Toronto, Toronto, Canada
12:30 - 14:00
Lunch
14:00 - 16:30
Open
16:30 - 18:30
Session 15
Oral presentations
Title
Perspectives on past and future of signalling modules
16:30 - 17:15
Session 9-T01-K-01
Protein phosphorylation and cell signaling: histidine phosphorylation
Tony Hunter
Salk Institute, La Jolla, United States
17:15 - 18:00
Session 9-T01-K-02
A PROTEIN KINASE-REGULATED RNA-BINDING PROTEIN NETWORK CONTROLS THE RESPONSE OF CANCER CELLS TO DNA DAMAGE.
Michael Yaffe, Ian Cannell, Konstantin Krismer, Yi-Wen Kong, Molly Bird, Shohreh Varmeh, Robert Grant
Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, and the Broad Institute, Cambridge, MA, United States
19:00 - 20:00
Cocktails
20:00 - 23:00
Banquet