Multivalent histone and DNA engagement by
the triple reader module of ZMYND8 directs the recruitment of a
transcriptional network to genes to regulate gene expression
Pavel Savitsky1, Tobias Krojer1, Takao Fujisawa2, Jean-Philippe Lambert3, Sarah Picaud1, Chen-Yi Wang2, Erin Shanle4, Krzysztof Krajewski4, Hans Friedrichsen2, Alexander Kanapin5, Panagis Filippakopoulos1, 2, et al.
1Structural Genomics
Consortium, Nuffield Department of Clinical Medicine, University of
Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3
7DQ, UK, Oxford, United Kingdom, 2Ludwig Institute for Cancer
Research, Nuffield Department of Clinical Medicine, University of
Oxford, Old Road Campus Research Building Roosevelt Drive, Oxford, OX3
7DQ, UK., Oxford, United Kingdom, 3Lunenfeld-Tanenbaum
Research Institute at Mount Sinai Hospital, 600 University Ave, Toronto,
ON, M5G 1X5, Canada., Toronto, Canada, 4Department of
Biochemistry and Biophysics, University of North Carolina at Chapel
Hill, Chapel Hill, NC 27599, USA, Chapel Hill, United States, 5Department
of Oncology, Gray Laboratories, University of Oxford, Old Road Campus
Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK, Oxford, United
Kingdom, 6Lineberger Comprehensive Cancer Center, University
of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Chapel
Hill, United States, 7Structural Genomics Consortium, MaRS
Centre, South Tower 101 College St., Suite 700 Toronto, ON, M5G 1L7
Canada., Toronto, Canada, 8Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada, Toronto, Canada, 9Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Toronto, Canada