20th - 23rd April| 2006 | Rome|Italy

April 20th (afternoon)

15:00 - Registration

16:15 - Welcome

Introduction to Redox signalling

Chairmen: S. Aloj (Naples, EU);
T. Galeotti (Rome, EU)

16:20 - S. G. Rhee (Bethesda, US):

“Signal transduction by H²O²”.

17:10 - T. Finkel (Bethesda, US):

“Redox signaling in human diseases: an overview”

18:00 - P. Chiarugi (Florence, EC):

“Oxidative tuning of protein tyrosine phosphorylation"

19:00 - - Cocktail reception at conference venue

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April 21st

Session 1: Redox signaling in angiogenesis and cancer

Chairmen: B. Giardina (Rome, EU); A. Cittadini (Rome, EU)

09.00 - F. Mechta-Grigoriou (Paris,EC):

"The role of AP-1 in oxidative stress and cancer".

09.40 - Ratcliffe PJ  (London, EC):

"Sensing Oxygen"

10.20 - C. Michiels (Namur, EC):

"Physiological and pathological responses to hypoxia"

11.00 - Break

11.20 - S.  Giordano (Turin, EC):

“Modulation of the cMet receptor by oxygen tension and Reactive Oxygen Species”

12.00 - F . Martelli (Rome, EU)):

“Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress ”

12.15 - N. Raimundo (Helsinki, EU):

“Fumarate hydratase deficiency and tumorigenesis: roiles of hypoxia and redox state ”

12.30 - A. Truempler (Jena,, EU):

“Oxidation-dependent degradation of protein tyrosine phosphatase 1B by calpain ”

12.45 - M.R. Ciriolo (Romei, EU):

“Role of GSH and ERK1/2 in the resistance of AGS adenocarcinoma gastgric cells to diallyl disulfide-induced apoptosis ”

13:00 - Lunch + Poster Session

 

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Session 2:
Redox  Signaling in inflammatory and degenerative disorders

Chairmen: C. Fraga (BuenosAires, AR); A.W. Segal (London, EU)

15:00 - A.W. Segal (London, EC):

"Role of ROS in innate immunity revisited"

15:40 - Patricia I Oteiza  (Davis, US):

“Modulation of NF-kB by micronutrients and natural compounds in activated lymphocytes”

16:20 - A. Holmgren  (Stockholm, EC):

“Thioredoxin and Glutaredoxin in disease"

17:00 - break

17:20 - A. Riccio (London, EC):

“Redox regulation of CREB-dependent gene expression ”

18:00 - C. Gaetano (Rome, EU):

“Laminar flow induces apoptosis in Human Endothelial Cells exposed to oxidative stress: Protective Role of p21 ”

18:15 - J. Lee (Chicago, US):

“Monoubiquitination of DEDD Mediates Intemediate Filament Reogranization and Apoptotic Potential ”

18:30 - A. De Luliis (Padua, EU):

“Oxidative metabolism of dopamine: a colour reaction analysed by mass spectrometry ”

18:45 - W. Malorni (Rome, EU):

“Role of reactive oxygen species in erythrocyte twisting between senescence and apoptosis ”

 

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April 22nd

Session 3:
Redox signaling in mitochondria

Chairmen: P. Bernardi (Padua, Eu); F. Esposito (Naples, EU)

09:00 - G. Kroemer (Paris, EC)

"Mitochondrial control of apoptosis"

09:40 - P. Bernardi (Padua, EC)

"Redox control of Mitochondrial permeability transition"

10:20 - JC Fernandez-Checa (Barcelona, EC) "

"Redox regulation and signaling lipids in mitochondrial apoptosis"

11.00 - Break

11:20 - MP Murphy  (Cambridge, EC)

"Therapeutic potential of  mitochondrially-targeted antioxidants"

12:00 - F. Esposito  (Naples, EU))

"The mithocondrial hsp75 trap-1 in the response to oxidative stress and chemoresistance".

12:20 - A. Rovio  (Tampere, EU))

"TMitochondrial DNA mutations and oxidative stress in ageing and male infertility "

12:45 - Lunch + Poster Session

 

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Session 4:
Ageing

14:30 - M. Holzenberger (Paris EC):

“Insulin signaling and ageing”

15:10 - P. Pelicci (Milan , EC):

“p66 ^shc, oxidative stress and longevity”

15:50 - T. Dansen (Utrecht, EC):

“ Interplay between c-myc and FOXO in cell survival to oxidative stress."

16:30 - Break

16:50 - G. Pani (Rome, EC):

“Regulation of cells survival by nutrient-related signals"

17:30- G. PLopez-Lluchi (Sevilla,EU):

“More and better mitochondria; a key anti-aging mechanism of calorie restriction "

17:45 - - R. Colavitti (Bethesda, US):

“Redox regulation of mTOR "

18:00 - F. Magherini (Florence, EU):

"Redox proteomics in yeast chronological ageing"

18:15 - J. Hsu (Boston, US):

“Genomic instability and Aging-Like Phenotype in SIRT-6 KO mice"

18:30 - 19:10 - "BIOTETHED Project-EMBO Science and Society lecture" 

A. Quintanihla (Porto, EU); D. Sacchini (Rome, EU)

"Bioethics of Ageing"

20:30 - Social Dinner

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April 23rd

09:00- Redox Signalling

Chairman: G. Pani (Rome, EU)

M. Carella (Jena, EU):

"NMR analysis of human type-b methionine sulfoxide reductases"

  T. Fiaschi (Florence, EU:

"Redox regulation of beta actin during integrin-mediated cell adhesion"

E. Giannoni (Florence, EU)

"The inhibithion of integrin-mediated cell adhesion by ephrinA1 is redox dependent"

S. Messina Iserniai (, EU)

"Reactive oxygen species (ROS) regulate Ha-ras in primary astrocytes via ERK1/2 "

S. Piccirillo ( Rome , EU)

"Hystotype-selective activation of MAP kinaes: different responses to different oxidative stresses"

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10:00  Cancer and Angiogenesis   
   
Chairman: P. Palozza  (Rome, EU)

P. Fasanaro (Rome, EU)

"PCyclin D1 degradation enhances Endothelial Cell survival upon oxidative stress"

G. Filomeni (Rome, EU)

"Pro-apoptotic effect of diallyl disulfide on SH-SY5Y neuroblastoma cells  is related on ROS  production and JNK activation."

D. Hoogeboom (Utrecht, EU)

"Interaction of FOXO with b-catenin inhibits b-catenin/TCF activity".

10:30  break

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11:00  Inflammmatory and degenerative disorders 

  Chairman: A. Riccio (London, EU)

C. Colussi (Rome, EU)

"Histone deacetylase inhibitors reverts chromatin remodelling dysfunction in the mdx mouse model of duchenne muscular dystrophy"

B. Illi (Milan, EU)

"Nitric Oxide Inhibits Histone Acetylation by Activation of class II HDACs in Vascular cells: Potential Implications for Atherogenesis".

M.C. Munteanu (Bucharest, RO)

"Manganese (ii) induces mitochondrial dependent apoptosis in huh7 cells"

M. Nitti (Genova, EU)

"Neuronal sensitivity to glycoxidative stress is related to PKC delta isoform expression".

J. Szemraj (Lodz, EU)

"The effects of oxidative stress on the expression of PAI-1, t-PA and uPA in vascular endothelial cells".

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12:00  Mitochondria and ageing  

  Chairman:  M. Murphy (Cambridge, EU)

U. Berge (Aarhus, EU)

"Modulation of Differentiation of Normal Human Epidermal Keratinocytes Undergoing Ageing In Vitro"

F. Buricchi (Florence, EU)

"Redox-dependent trans-activation of insulin receptor by adiponectin"

G. Zaccagnini (Rome, EU)

"p66ShcA deletion enhances tissue regeneration following ischemia"

12:30   Closing remarks

 

13:00  Lunch

 

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